JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB242269

violetFluor™ 450 Anti-CD11c antibody [N418]

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Anti-CD11c antibody [N418] conjugated to violetFluor™ 450 - suitable for flow cytometry, and reacts with mouse samples. Clone [N418] is a Armenian Hamster monoclonal antibody and one of the most commonly used clones for flow cytometry.

Design your panel with our interactive flow cytometry panel builder. Click here.
1 이미지
Flow Cytometry - violetFluor™ 450 Anti-CD11c antibody [N418] (AB242269)
  • Flow Cyt

Supplier Data

Flow Cytometry - violetFluor™ 450 Anti-CD11c antibody [N418] (AB242269)

Flow cytometric analysis of C57Bl/6 splenocytes labeling CD11c using ab242269 at 0.125 μg (Right) compared to 0.125 ug violetFluor™ 450 Armenian Hamster IgG (left panel).

관련 conjugated 항체와 다양한 조성의 항체 (2)

주요 정보

Host species

Armenian hamster

Clonality

Monoclonal

Clone number

N418

Isotype

IgG

Conjugation

violetFluor™ 450

Excitation/Emission

Ex: 405nm, Em: 450nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing Itgax protein. The exact immunogen used to generate this antibody is proprietary information.

Q9QXH4

style
left-column

대체품

Primary Antibodies

AB11029

Anti-CD11c antibody [3.9]

Trial Size|Trial Size|Trial Size|Trial Size|Trial Size

Flow Cytometry - Anti-CD11c antibody [3.9] (AB11029)

  • 4
  • 11
Primary Antibodies

AB133246

Anti-CD11c antibody [EPR1346]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-CD11c antibody [EPR1346] (AB133246)

  • 0
  • 0
Primary Antibodies

AB195534

HRP Anti-CD11c antibody [EP1347Y]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HRP Anti-CD11c antibody [EP1347Y] (AB195534)

  • 0
  • 0
Primary Antibodies

AB216655

Anti-CD11c antibody [EP1347Y] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EP1347Y] - BSA and Azide free (AB216655)

  • 4
  • 11
Primary Antibodies

AB219799

Anti-CD11c antibody [EPR21826]

20ul selling size|RabMAb|Recombinant

Flow Cytometry - Anti-CD11c antibody [EPR21826] (AB219799)

  • 4
  • 8
Primary Antibodies

AB240558

Anti-CD11c antibody [EPR21826] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD11c antibody [EPR21826] - BSA and Azide free (AB240558)

  • 4
  • 1
Primary Antibodies

AB52632

Anti-CD11c antibody [EP1347Y] - C-terminal

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD11c antibody [EP1347Y] - C-terminal (AB52632)

  • 5
  • 18
Primary Antibodies

AB264107

Anti-CD11c antibody [3.9] - BSA and Azide free

Flow Cytometry - Anti-CD11c antibody [3.9] - BSA and Azide free (AB264107)

  • 0
  • 0

보완 제품

Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB237365

Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769] (AB237365)

  • 0
  • 0
Primary Antibodies

AB252149

Alexa Fluor® 488 Anti-CD4 antibody [EPR20122]

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-CD4 antibody [EPR20122] (AB252149)

  • 0
  • 0
Primary Antibodies

AB307134

Alexa Fluor® 488 Anti-CD3 antibody [SP162]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-CD3 antibody [SP162] (AB307134)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use 0.125 μg.</p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
보관 버퍼
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store in the dark
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.
Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis.
See full target information Itgax

대체 명칭 보기

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com