violetFluor™ 500 Anti-MHC Class II (I-A/I-E) antibody [M5/114.15.2]

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This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

MHC Class II molecules contribute significantly to the adaptive immune response forming part of the peptide-MHC complex. This complex presents processed antigen fragments to T cells. When T cell receptors on CD4+ T cells recognize and bind to these peptide-MHC complexes it triggers signaling cascades that result in T cell activation proliferation and differentiation. The I Ab + Ad refers to specific alleles in different strains of mice models critical for experimental studies in immunology.

Pathways

MHC Class II molecules play an important role in the antigen processing and presentation pathway an essential mechanism for adaptive immune responses. Additionally they participate in the toll-like receptor signaling pathway that helps recognize pathogen-associated molecular patterns. The pathway interactions involve other key proteins like CD4 which is a co-receptor that works alongside T cell receptors to enhance antigen recognition and signaling during immune responses.