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AB4731

Anti-WRNIP1/WHIP antibody

5

(1 리뷰)

|

(3 제품이 사용된 논문 )

Rabbit Polyclonal WRNIP1/WHIP antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

<p>Reactivity is expected against human, mouse, rat and monkey WHIP1 protein.</p>

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대체품

Primary Antibodies

AB99316

Anti-WRNIP1/WHIP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WRNIP1/WHIP antibody (AB99316)

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  • 1
Primary Antibodies

AB18729

Anti-WRNIP1/WHIP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WRNIP1/WHIP antibody (AB18729)

  • 0
  • 0

보완 제품

Primary Antibodies

AB224221

Anti-WDHD1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-WDHD1 antibody (AB224221)

  • 0
  • 0
Primary Antibodies

AB6326

Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker

Flow Cytometry (Intracellular) - Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker (AB6326)

  • 5
  • 104
Primary Antibodies

AB316954

Anti-FENS1/WDFY1 antibody

Western blot - Anti-FENS1/WDFY1 Antibody (AB316954)

  • 0
  • 0
Primary Antibodies

AB133741

Anti-Lamin B1 antibody [EPR8985(B)] - Nuclear Envelope Marker

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Lamin B1 antibody [EPR8985(B)] - Nuclear Envelope Marker (AB133741)

  • 4
  • 15
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide immobilized to a solid phase.
보관 버퍼
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The WRNIP1/WHIP protein also known as Werner helicase interacting protein 1 (WRNIP1) plays a role in DNA repair processes. It has a molecular mass of approximately 72 kDa. WRNIP1 is expressed in multiple tissues with notable expression in the nucleus of proliferating cells. Mechanically the protein interacts with the Werner syndrome ATP-dependent helicase (WRN) and modulates its activity during the processing of stalled replication forks. Its interaction with DNA binding proteins is important to maintaining genomic stability.
Biological function summary

This protein aids cellular processes involved in DNA replication and repair. WRNIP1 forms part of a complex that includes proteins involved in the stabilization and restart of collapsed replication forks. The protein facilitates the stabilization and elongation of DNA strands playing a role in homologous recombination repair. The action of WRNIP1 extends to cell cycle regulation by ensuring repair precision before mitosis proceeds.

Pathways

WRNIP1 integrates into processes linked with the replication stress response and homologous recombination repair pathways. In these pathways it collaborates with proteins such as RAD51 an essential player in homologous recombination. Additionally WRNIP1 acts in cohesion with WRN influencing pathways that mitigate the risk of cancer by preventing excessive genomic alterations. These pathways are essential for the proper resolution of replication fork stalling situations.

WRNIP1 is closely associated with Werner syndrome and cancer predisposition. Its dysfunction can lead to defects in DNA repair mechanisms increasing susceptibility to such disorders. Along with WRN any alterations could potentially lead to faulty repair of DNA damage paving a way for oncogenesis. Researchers investigate WRNIP1 concerning its protective role against replication stress-induced genomic instability and its potential implications in drug resistance within cancer treatment strategies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS.
See full target information WRNIP1

대체 명칭 보기

WHIP, WRNIP1, ATPase WRNIP1, Werner helicase-interacting protein 1
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Proceedings of the National Academy of Sciences of the United States of America 119:e2117175119 PubMed36179048

2022

Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.

Applications

Unspecified application

Species

Unspecified reactive species

Rodolfo Ciuffa,Federico Uliana,Jonathan Mannion,Martin Mehnert,Tencho Tenev,Cathy Marulli,Ari Satanowski,Lena Maria Leone Keller,Pilar Natalia Rodilla Ramírez,Alessandro Ori,Matthias Gstaiger,Pascal Meier,Ruedi Aebersold

Oncogene 35:4009-19 PubMed26549024

2015

RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.

Applications

Unspecified application

Species

Unspecified reactive species

N Kanu,T Zhang,R A Burrell,A Chakraborty,J Cronshaw,C DaCosta,E Grönroos,H N Pemberton,E Anderton,L Gonzalez,S Sabbioneda,H D Ulrich,C Swanton,A Behrens

Cancer science 98:1902-13 PubMed17888034

2007

Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.

Applications

ICC/IF

Species

Human

Yuria Mano,Koji Takahashi,Nobuhisa Ishikawa,Atsushi Takano,Wataru Yasui,Kouki Inai,Hitoshi Nishimura,Eiju Tsuchiya,Yusuke Nakamura,Yataro Daigo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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