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AB243712

Anti-XPO6 antibody

5

(2 리뷰들)

|

(1 출판물)

Rabbit Polyclonal XPO6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human XPO6 aa 900 to C-terminus.

대체 명칭 보기

KIAA0370, RANBP20, XPO6, Exportin-6, Exp6, Ran-binding protein 20

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XPO6 antibody (AB243712)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XPO6 antibody (AB243712)

Formalin-fixed, paraffin-embedded human kidney tissue stained for XPO6 using ab243712 at 1/500 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-XPO6 antibody (AB243712)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-XPO6 antibody (AB243712)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for XPO6 (green) using ab243712 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human XPO6 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96QU8

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보완 제품

Primary Antibodies

AB175925

Anti-RAB11B antibody [EPR12725]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-RAB11B antibody [EPR12725] (AB175925)

  • 5
  • 1
Primary Antibodies

AB262926

Anti-ARHGAP18 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ARHGAP18 antibody (AB262926)

  • 0
  • 0
Primary Antibodies

AB256487

Anti-RAB12 (phospho S106) antibody [MJF-R25-9]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-RAB12 (phospho S106) antibody [MJF-R25-9] (AB256487)

  • 0
  • 0
Primary Antibodies

AB122666

Anti-RAB12 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB12 antibody (AB122666)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The exportin 6 (XPO6) also known as exportin T is a protein involved in nuclear export processes. It has a molecular mass of about 130 kDa. XPO6 is expressed in various tissues including the liver kidney and skeletal muscle where it facilitates the transport of specific proteins and RNA from the nucleus to the cytoplasm. XPO6 functions by binding to its cargo and navigating through the nuclear pore complex effectively regulating intracellular transport.
Biological function summary

Exportin 6 is responsible for the export of profilin-actin complexes from the nucleus playing an important role in maintaining cellular actin equilibrium. It is not part of a multi-protein complex per se but its interaction with cargo molecules involves recognizing nuclear export signals. XPO6's function extends beyond transport influencing cytoskeletal dynamics by regulating actin monomer availability within the cell which is essential for various cellular functions like motility and division.

Pathways

The activities of XPO6 intersect with the Ran GTPase pathway. This pathway facilitates the transport of proteins and RNA between the nucleus and cytoplasm where XPO6 collaborates with Ran GTPase to recognize and bind nuclear export signals of its cargo proteins. XPO6 also interacts with importins and other exportins ensuring balanced nuclear-cytoplasmic transport necessary for cellular homeostasis and response to environmental changes.

Dysregulation of XPO6 has associations with cancer particularly in tumors where actin dynamics are altered. Abnormal expression of XPO6 can disrupt actin balance influencing cell proliferation and migration hallmarks of cancer progression. Additionally XPO6 is connected to neurodegenerative diseases through its impact on cytoskeletal stability. Alterations in XPO6 expression or function can contribute to impaired neuronal transport processes. In both contexts exportin 6 relates to the dysregulation of proteins such as profilin whose stability and localization are critical for normal cellular function.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.
See full target information XPO6
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Science advances 9:eadg2339 PubMed37352355

2023

VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqiang Hu,Yingchao Xie,Jiansen Lu,Jianwu Yang,Jiahuan Zhang,Huaji Jiang,Hongyu Li,Yufeng Zhang,Dan Wu,Ke Zeng,Xiaochun Bai,Xiao Yu
제품이 사용된 논문 모두 보기
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Product promise

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