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AB97390

Anti-XRCC3 antibody

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Rabbit Polyclonal XRCC3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DNA repair protein XRCC3 aa 200 to C-terminus.
2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-XRCC3 antibody (AB97390)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-XRCC3 antibody (AB97390)

ab97390, at a 1/200 dilution, staining XRCC3 in paraformaldehyde fixed HeLa by Immunofluorescence.
Lower image was merged with DNA probe.

Western blot - Anti-XRCC3 antibody (AB97390)
  • WB

Unknown

Western blot - Anti-XRCC3 antibody (AB97390)

All lanes:

Western blot - Anti-XRCC3 antibody (ab97390) at 1/1000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 37 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human DNA repair protein XRCC3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43542

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대체품

Primary Antibodies

AB58467

Anti-XRCC3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC3 antibody (AB58467)

  • 0
  • 0
Primary Antibodies

AB20254

Anti-XRCC3 antibody [XRCC3 10F1/6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC3 antibody [XRCC3 10F1/6] (AB20254)

  • 4
  • 2

보완 제품

Primary Antibodies

AB133534

Anti-Rad51 antibody [EPR4030(3)]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Rad51 antibody [EPR4030(3)] (AB133534)

  • 4
  • 15
Primary Antibodies

AB74032

Anti-MAPK6/ERK3 (phospho S189) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAPK6/ERK3 (phospho S189) antibody (AB74032)

  • 0
  • 0
Primary Antibodies

AB223733

Anti-TYK2 antibody

KO Validated

Western blot - Anti-TYK2 antibody (AB223733)

  • 0
  • 0
Primary Antibodies

AB53277

Anti-MAPK6/ERK3 antibody [EP1720Y]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAPK6/ERK3 antibody [EP1720Y] (AB53277)

  • 1
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

XRCC3 also known as X-Ray Repair Cross Complementing 3 plays an important role in DNA repair processes. It is a protein weighing approximately 39 kDa and is expressed in many tissues within the human body. This protein belongs to the RAD51 family of recombinases and is essential during homologous recombination ensuring the stability and integrity of the genome by assisting in the repair of double-strand breaks in DNA.
Biological function summary

XRCC3 promotes DNA repair and genomic stability and functions as part of a complex. It associates with other proteins in the RAD51 family to facilitate the proper repair mechanisms required for maintaining cellular health. XRCC3’s activity in homologous recombination is critical to prevent DNA damage accumulation which could lead to chromosomal abnormalities impacting cell survival and proliferation.

Pathways

XRCC3 is integrally involved in homologous recombination repair and the broader DNA damage response network. It interacts closely with RAD51 and BRCA2 to mediate accurate DNA repair by homologous recombination ensuring precise repair pathway activation and reducing erroneous repair activities. XRCC3 supports the recruitment of RAD51 to DNA breaks and collaborates with the Fanconi anemia pathway to protect against genomic instability.

XRCC3 mutations or dysfunctions have associations with cancer susceptibility particularly breast cancer. The protein’s role in DNA repair links it to other proteins like BRCA1 and BRCA2 which have established connections in hereditary breast and ovarian cancer syndromes. Altered XRCC3 expression or sequence changes can compromise DNA repair pathways heightening the risk of tumorigenesis due to unchecked DNA damage accumulation.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
See full target information DNA repair protein XRCC3

대체 명칭 보기

DNA repair protein XRCC3, X-ray repair cross-complementing protein 3, XRCC3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer research 74:1651-60 PubMed24473064

2014

PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.

Applications

WB

Species

Unspecified reactive species

John R Prensner,Wei Chen,Matthew K Iyer,Qi Cao,Teng Ma,Sumin Han,Anirban Sahu,Rohit Malik,Kari Wilder-Romans,Nora Navone,Christopher J Logothetis,John C Araujo,Louis L Pisters,Ashutosh K Tewari,Christine E Canman,Karen E Knudsen,Naoki Kitabayashi,Mark A Rubin,Francesca Demichelis,Theodore S Lawrence,Arul M Chinnaiyan,Felix Y Feng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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