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AB236425

Anti-XRCC6BP1/KUB3 antibody [OTI5F3]

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Mouse Monoclonal XRCC6BP1/KUB3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ATP23.

대체 명칭 보기

KUB3, XRCC6BP1, ATP23, Mitochondrial inner membrane protease ATP23 homolog, Ku70-binding protein 3, XRCC6-binding protein 1

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC6BP1/KUB3 antibody [OTI5F3] (AB236425)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC6BP1/KUB3 antibody [OTI5F3] (AB236425)

Paraffin-embedded human endometrium adenocarcinoma tissue stained for XRCC6BP1/KUB3 using ab236425 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC6BP1/KUB3 antibody [OTI5F3] (AB236425)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC6BP1/KUB3 antibody [OTI5F3] (AB236425)

Paraffin-embedded human bladder tissue stained for XRCC6BP1/KUB3 using ab236425 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC6BP1/KUB3 antibody [OTI5F3] (AB236425)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRCC6BP1/KUB3 antibody [OTI5F3] (AB236425)

Paraffin-embedded human ovary adenocarcinoma tissue stained for XRCC6BP1/KUB3 using ab236425 at 1/150 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI5F3

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ATP23.

Q9Y6H3

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보완 제품

Primary Antibodies

AB2792

Anti-P4HB antibody [RL90]

Immunocytochemistry/ Immunofluorescence - Anti-P4HB antibody [RL90] (AB2792)

  • 4
  • 48
Primary Antibodies

AB168372

Anti-Fbx32 antibody [EPR9148(2)]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Fbx32 antibody [EPR9148(2)] (AB168372)

  • 5
  • 2
Primary Antibodies

AB183094

Anti-MURF1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MURF1 antibody (AB183094)

  • 5
  • 1
Primary Antibodies

AB22595

Anti-Calnexin antibody - ER Marker

Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Calnexin antibody - ER Marker (AB22595)

  • 5
  • 28
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p>Perform heat-induced epitope retrieval by 1 mM EDTA in 10 mM Tris buffer (pH 8.5) at 120°C for 3 minutes.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

XRCC6BP1 also known as KUB3 is a protein that plays a mechanical role in maintaining genome stability. It has a molecular mass of approximately 81 kDa. XRCC6BP1 exhibits expression in a variety of tissues but it has higher levels in areas with active cell proliferation. Its functions involve interactions with other proteins to ensure the structural integrity of DNA.
Biological function summary

XRCC6BP1 participates in the repair of DNA double-strand breaks important for preventing genomic instability. It forms part of multi-protein complexes that facilitate correct DNA damage recognition and repair. XRCC6BP1 engages in interactions with proteins involved in non-homologous end joining an important DNA repair pathway. By doing this it supports cellular responses to DNA damage maintaining a correct cellular cycle.

Pathways

XRCC6BP1 integrates DNA repair processes into broader signaling networks. It actively participates in the non-homologous end joining pathway important for DNA repair. XRCC6BP1 also connects to the homologous recombination repair pathway indicating its versatile role. Related proteins such as XRCC6 (Ku70) and XRCC5 (Ku80) identify and bind to DNA break sites facilitating the recruitment of XRCC6BP1 for repair synthesis.

XRCC6BP1's function correlates with cancer and some genetic disorders. Deficiencies or dysfunctions in XRCC6BP1 can lead to improper DNA repair contributing to genomic instability an important feature in cancer development. Research also investigates its disruptions in disorders such as ataxia-telangiectasia where repair mechanisms fail. Its relationship with other proteins involved in these diseases such as ATM signifies its impact on maintaining DNA integrity under stress conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information ATP23
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Thoracic cancer 16:e70079 PubMed40324967

2025

NAT10 Knockdown Improves Cisplatin Sensitivity in Non-Small Cell Lung Cancer by Inhibiting the TRIM44/PI3K/AKT Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Sun,Xiansong Yang,Ye Wang,Kejia Yang,Yuan Weng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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