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AB235784

Anti-XRRA1 antibody

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Rabbit Polyclonal XRRA1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human X-ray radiation resistance-associated protein 1 aa 1 to C-terminus.

대체 명칭 보기

X-ray radiation resistance-associated protein 1, XRRA1

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRRA1 antibody (AB235784)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRRA1 antibody (AB235784)

Paraffin-embedded human small intestine tissue stained for XRRA1 using ab235784 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human X-ray radiation resistance-associated protein 1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6P2D8

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보완 제품

Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF695 antibody (AB237811)

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Primary Antibodies

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Anti-RBP4 antibody [EPR18020-115]

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Primary Antibodies

AB96073

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Primary Antibodies

AB92516

Anti-Calreticulin antibody [EPR3924] - ER Marker

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Calreticulin antibody [EPR3924] - ER Marker (AB92516)

  • 4
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

XRRA1 also known as X-ray radiation resistance-associated protein 1 has a role in cellular responses to radiation. This protein weighs approximately 33 kDa and localizes mainly to the nucleus. It is expressed in several tissues with noteworthy presence in testis and breast tissue. XRRA1 interacts with elements involved in DNA damage repair playing a role in modulating cellular defense mechanisms against radiation.
Biological function summary

XRRA1 influences cellular tolerance and adaptation to radiation-induced stress. This protein associates with components of genetic regulatory networks involved in preserving genomic stability. It does not form an extensive complex but participates in protein interactions that facilitate cell cycle checkpoints and DNA repair processes. Through its functions XRRA1 aids in controlling cellular environments under stress conditions.

Pathways

XRRA1 acts within the DNA damage response pathway which is critical for maintaining genomic integrity. It interacts with proteins such as ATM and BRCA1 which are key in sensing DNA breaks and coordinating repair processes. Besides XRRA1 has implications in the MAPK signaling pathway interplaying with proteins affecting cell proliferation and survival mechanisms in response to external stimuli.

XRRA1 has associations with various cancers notably breast cancer. The connection occurs through its influence on pathways that handle DNA repair and apoptosis which when impaired contribute to carcinogenesis. XRRA1's role also extends to disorders linked to radiation sensitivity such as ataxia-telangiectasia where the presence of XRRA1 impacts cellular repair dynamics. Through these connections XRRA1 becomes a target of interest for therapeutic interventions in conditions with misregulation of radiation response mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May be involved in the response of cells to X-ray radiation.
See full target information X-ray radiation resistance-associated protein 1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

OncoTargets and therapy 14:3721-3728 PubMed34140780

2021

G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yunfen Li,Zhengting Chen,Ke Cao,Lan Zhang,Yuhui Ma,Shuhui Yu,Hanyu Jin,Xiaoling Liu,Wenhui Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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