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AB224224

Anti-YIPF6 antibody

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Rabbit Polyclonal YIPF6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human YIPF6 aa 1-100.

대체 명칭 보기

Protein YIPF6, YIP1 family member 6, YIPF6

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-YIPF6 antibody (AB224224)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-YIPF6 antibody (AB224224)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for YIPF6 (green) using ab224224 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-YIPF6 antibody (AB224224)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-YIPF6 antibody (AB224224)

Paraffin-embedded human epididymis tissue stained for YIPF6 using ab224224 at 1/50 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human YIPF6 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q96EC8

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보완 제품

Primary Antibodies

AB223505

Anti-YIPF3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-YIPF3 antibody (AB223505)

  • 0
  • 0
Primary Antibodies

AB235050

Anti-CHMP6/VPS20 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHMP6/VPS20 antibody (AB235050)

  • 3
  • 1
Primary Antibodies

AB118554

Anti-PARL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PARL antibody (AB118554)

  • 0
  • 0
Primary Antibodies

AB195380

Anti-WTAP antibody [EPR18744]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-WTAP antibody [EPR18744] (AB195380)

  • 5
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

YIPF6 also known as YIP1 family member 6 is a protein involved in vesicular transport and membrane trafficking. It has a molecular mass of approximately 35 kDa. The protein localizes primarily at the Golgi apparatus and is expressed in various tissues particularly in those with high secretory functions such as the liver and pancreas. YIPF6 plays a significant role in maintaining Golgi structure and function by interacting with other Golgi-associated proteins.
Biological function summary

YIPF6 participates in the formation and maintenance of the Golgi complex. It functions as part of a larger protein complex collaborating with Rab Arf and other YIP family proteins to regulate vesicle budding and fusion. This activity is essential for proper protein and lipid trafficking within cells ensuring that the cellular export and import processes proceed efficiently. The protein's interactions with various co-factors highlight its role in sustaining intracellular logistics.

Pathways

YIPF6 is an essential component of the vesicular transport system and intracellular trafficking pathways. It closely associates with the COPI (coat protein complex I) pathway which mediates retrograde transport from the Golgi to the endoplasmic reticulum. YIPF6 also engages in related functions with proteins such as ARF1 a small GTPase critical for vesicle formation. These pathways highlight the protein's role in facilitating cellular transport mechanisms that are important for maintaining homeostasis within the cell.

YIPF6's dysfunction can link to conditions involving protein misfolding and trafficking defects such as certain neurodegenerative diseases. Mutations or alterations in YIPF6 may also relate to metabolic disorders where liver and pancreatic functions are compromised. Its connection with proteins like Rab GTPases and ARF1 emphasizes its involvement in the underlying pathophysiology of these diseases as these associated proteins play roles in the same trafficking pathways that could lead to cellular stress and impairment when disrupted.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May be required for stable YIPF1 and YIPF2 protein expression.
See full target information YIPF6
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature 633:932-940 PubMed39232161

2024

CDK5-cyclin B1 regulates mitotic fidelity.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Feng Zheng,Aniruddha Sarkar,Humphrey Lotana,Aleem Syed,Huy Nguyen,Richard G Ivey,Jacob J Kennedy,Jeffrey R Whiteaker,Bartłomiej Tomasik,Kaimeng Huang,Feng Li,Alan D D'Andrea,Amanda G Paulovich,Kavita Shah,Alexander Spektor,Dipanjan Chowdhury
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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