AB185106

Anti-ZASC1 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal ZASC1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF639 aa 100-200.

대체 명칭 보기

ZASC1, ZNF639, Zinc finger protein 639, Zinc finger protein ANC_2H01, Zinc finger protein ZASC1

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)

Immunofluorescence analysis of MCF7 cells labeling ZASC1 using ab185106 at 4 μg/ml.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)

Immunohistochemical analysis of paraffin-embedded Human rectum tissue, labeling ZASC1 using ab185106 at a 1/500 dilution.

Supplier Data

Western blot - Anti-ZASC1 antibody (AB185106)

All lanes:

Western blot - Anti-ZASC1 antibody (ab185106) at 1/500 dilution

Lane 1:

RT-4 cell lysate

Lane 2:

U251 MG sp lysate

Lane 3:

Human plasma (IgG/HSA depleted)

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 56 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human ZNF639 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9UID6

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol</p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ZASC1 also known as Zinc finger protein 618 with SCAN box is a transcription factor characterized by the presence of a SCAN domain and multiple zinc finger motifs. It has an approximate molecular mass of 93 kDa. This protein is largely expressed in the testis with lower levels present in additional tissues such as the heart and brain. The presence of zinc finger domains indicates its potential role in DNA binding and gene regulation.

Biological function summary

ZASC1 is involved in modulating the transcriptional activities of genes by binding to specific DNA sequences. In its function as a transcription factor ZASC1 interacts with other proteins to form a regulatory complex that influences gene expression patterns. This protein plays a role in cellular processes such as differentiation and proliferation by impacting the transcription of genes necessary for these processes.

Pathways

ZASC1 participates in several essential cellular pathways including those linked to gene expression regulation in the cell cycle. Within these pathways it works in conjunction with other transcription factors and signaling proteins such as the CREB-binding protein to fine-tune the transcriptional response. This interaction serves to coordinate the cellular activities important for maintaining normal function and development.

ZASC1 has implications in conditions like cancer and infertility. Altered expression or mutations in its coding sequence are associated with the dysregulation of cell growth implicating it in oncogenic processes. It also associates with other proteins like c-Myc in various cancer types highlighting its significance in cancer biology. Additionally inappropriate expression of ZASC1 may disrupt spermatogenesis leading to infertility highlighting its importance in reproductive health.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Binds DNA and may function as a transcriptional repressor.

See full target information ZNF639

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of breast cancer 28:86-98 PubMed40133986

2025

Zinc Finger Protein 639 Expression Is a Novel Prognostic Determinant in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Lee,Shih-Ping Cheng,Ming-Jen Chen,Wen-Chien Huang,Yi-Min Liu,Shao-Chiang Chang,Yuan-Ching Chang

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:1648-1665 PubMed35017224

2022

KCTD8 and KCTD12 Facilitate Axonal Expression of GABA Receptors in Habenula Cholinergic Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yuqi Ren,Yang Liu,Sanduo Zheng,Minmin Luo

PLoS pathogens 17:e1009364 PubMed33635925

2021

ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses.

Applications

Unspecified application

Species

Unspecified reactive species

James W Bruce,Megan Bracken,Edward Evans,Nathan Sherer,Paul Ahlquist

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZASC1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZASC1 antibody (AB185106)

Western blot - Anti-ZASC1 antibody (AB185106)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise