JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB217757

Anti-ZDHHC9 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal ZDHHC9 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZDHHC9 aa 100-150 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

CXorf11, ZDHHC10, ZNF379, ZNF380, CGI-89, UNQ261/PRO298, ZDHHC9, Palmitoyltransferase ZDHHC9, Zinc finger DHHC domain-containing protein 9, Zinc finger protein 379, Zinc finger protein 380, DHHC-9, DHHC9

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ZDHHC9 aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9Y397

style
left-column

대체품

Primary Antibodies

AB74504

Anti-ZDHHC9 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZDHHC9 antibody (AB74504)

  • 0
  • 0

보완 제품

Primary Antibodies

AB200572

Anti-DHHC-5 antibody

Immunoprecipitation - Anti-DHHC-5 antibody (AB200572)

  • 0
  • 0
Primary Antibodies

AB138210

Anti-ZDHHC7 antibody

  • 1
  • 1
Primary Antibodies

AB252922

Anti-CD36 antibody [EPR22509-40]

RabMAb|Recombinant|20ul selling size

Flow Cytometry - Anti-CD36 antibody [EPR22509-40] (AB252922)

  • 0
  • 0
Proteins & Peptides

AB196401

Recombinant human CARM1 protein (DDDDK tag N-Terminus)

Functional Studies - Recombinant human CARM1 protein (DDDDK tag N-Terminus) (AB196401)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ZDHHC9 also known as DHHC9 is a protein that functions as a palmitoyltransferase catalyzing the addition of palmitate a fatty acid to cysteine residues on substrate proteins. This post-translational modification known as S-palmitoylation regulates protein stability localization and interactions. ZDHHC9 has a molecular weight of approximately 39 kDa and is widely expressed in various tissues including the brain and heart. The protein localizes to the Golgi apparatus and affects the membrane association of its substrate proteins.
Biological function summary

ZDHHC9 influences cellular signaling and protein trafficking. It forms a complex with GCP16 another subunit enhancing its palmitoylation activity. ZDHHC9 regulates the palmitoylation of proteins involved in signaling pathways such as Ras proteins. This modification affects Ras proteins' membrane localization and function impacting cellular communication and signaling events. By modulating these pathways ZDHHC9 plays a part in maintaining normal cell physiology.

Pathways

ZDHHC9 modifies signal transduction pathways like the MAPK/ERK and the NF-κB pathways. The palmitoylated proteins especially H-Ras and N-Ras are integral to these signaling pathways that control cell growth differentiation and survival. The enzyme’s activity affects the dynamic regulation of these pathways influencing how cells respond to external stimuli. By interacting with these Ras proteins ZDHHC9 indirectly impacts pathways that regulate essential cellular processes.

Mutations or dysregulation of ZDHHC9 have associations with mental retardation and X-linked cognitive impairment. These conditions relate to altered Ras signaling where ZDHHC9 mutations impact normal Ras palmitoylation and function. Moreover defects in this protein have connections to developmental abnormalities due to disruptions in signal transduction during brain development. Understanding ZDHHC9's interactions with proteins like Ras provides insight into these complex disorders and potential therapeutic targets.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, GSDMD, HRAS, NRAS and CGAS (PubMed : 16000296, PubMed : 27481942, PubMed : 37802025, PubMed : 38530158, PubMed : 38599239). The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (PubMed : 16000296). May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed : 27481942). Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity (PubMed : 37802025). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed : 38530158, PubMed : 38599239).. (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.
See full target information ZDHHC9
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Regenerative therapy 20:165-186 PubMed35620640

2022

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish.

Applications

Unspecified application

Species

Unspecified reactive species

Tsubasa Saeki,Sho Yoshimatsu,Mitsuru Ishikawa,Chung-Chau Hon,Ikuko Koya,Shinsuke Shibata,Makoto Hosoya,Chika Saegusa,Kaoru Ogawa,Jay W Shin,Masato Fujioka,Hideyuki Okano
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com