AB254715

Anti-ZNF503 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal ZNF503 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF503 aa 100-300.

대체 명칭 보기

NOLZ1, ZNF503, Zinc finger protein 503

6 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Paraffin-embedded human endometrium tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Paraffin-embedded human prostate tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Paraffin-embedded human tonsil tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis. Low positivity in lymphoid cells.

Immunocytochemistry/ Immunofluorescence - Anti-ZNF503 antibody (AB254715)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF503 antibody (AB254715)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling ZNF503 using ab254715 at 4µg/ml (green) in ICC/IF.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Paraffin-embedded human rectum tissue stained for ZNF503 using ab254715 at 1/200 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-ZNF503 antibody (AB254715)

All lanes:

Western blot - Anti-ZNF503 antibody (ab254715) at 0.4 µg/mL

Lane 1:

PC-3 cell lysate

Lane 2:

MCF7 cell lysate

Predicted band size: 63 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ZNF503 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.

Q96F45

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ZNF503 also known as Zfp503 or Zeppo1 is a zinc finger protein with a molecular weight of approximately 55 kDa. ZNF503 consists of zinc finger domains which contribute to its function as a transcription factor. This protein is expressed in several tissues including the brain heart and lungs. ZNF503 interacts with DNA to either activate or repress transcription of specific genes controlling various cellular processes.

Biological function summary

ZNF503 plays an important role in the regulation of development and differentiation processes. It often functions as part of a transcriptional regulatory complex. This protein modulates the transcriptional activity affecting gene expression profiles according to the cellular context. It is essential in early embryonic development and neuronal differentiation contributing to the proper formation and function of these tissues.

Pathways

ZNF503 is a significant modulator of the Wnt signaling pathway which influences cell growth differentiation and migration. In the context of Wnt signaling ZNF503 interacts with other key proteins such as β-catenin facilitating Wnt pathway regulation. ZNF503 also associates with the Notch signaling pathway where it impacts cellular communication and fate decisions by interacting with components like Notch receptors and ligands.

ZNF503 has been implicated in cancer and neurodevelopmental disorders. Aberrant expression of ZNF503 is linked to tumorigenesis particularly in breast cancer where it interacts with proteins like HER2 to promote cancerous growth. In developmental disorders such as intellectual disabilities ZNF503 may influence neural development through its interactions with proteins involved in synaptic formation and maintenance leading to cognitive impairments when dysregulated.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May function as a transcriptional repressor.

See full target information ZNF503

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Bioengineered 13:5103-5112 PubMed35164665

2022

RAB27B inhibits proliferation and promotes apoptosis of leukemic cells via 3-Hydroxy butyrate dehydrogenase 2 (BDH2).

Applications

Unspecified application

Species

Unspecified reactive species

Can Meng,Li Huang,Xiangjun Fu,Bin Wu,Lie Lin

OncoTargets and therapy 13:6361-6371 PubMed32669856

2020

LncRNA TTN-AS1 Promotes Progression of Non-Small Cell Lung Cancer via Regulating miR-491-5p/ZNF503 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Guanbin Qi,Lei Li

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZNF503 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Immunocytochemistry/ Immunofluorescence - Anti-ZNF503 antibody (AB254715)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

Western blot - Anti-ZNF503 antibody (AB254715)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise