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AB240699

Anti-ZNF592 antibody

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Rabbit Polyclonal ZNF592 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF592 aa 200-250.

대체 명칭 보기

KIAA0211, ZNF592, Zinc finger protein 592

2 이미지
Immunoprecipitation - Anti-ZNF592 antibody (AB240699)
  • IP

Supplier Data

Immunoprecipitation - Anti-ZNF592 antibody (AB240699)

ZNF592 was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) using ab240699 at 3 μg/mL. Western blot was performed on the immunoprecipitate using ab240699 at 1 μg/mL.

Lane 1 : ab240699 IP in HeLa whole cell lysate.
Lane 2 : Control IgG (-).

Detection : Chemiluminescence with an exposure time of 3 seconds.

All lanes:

Immunoprecipitation - Anti-ZNF592 antibody (ab240699)

Predicted band size: 138 kDa

false

Western blot - Anti-ZNF592 antibody (AB240699)
  • WB

Supplier Data

Western blot - Anti-ZNF592 antibody (AB240699)

All lanes:

Western blot - Anti-ZNF592 antibody (ab240699) at 0.04 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 15 µg

Lane 3:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 5 µg

Predicted band size: 138 kDa

true

Exposure time: 10s

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human ZNF592 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

Q92610

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보완 제품

Primary Antibodies

AB229979

Anti-EFCAB7 antibody

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Primary Antibodies

AB211328

Anti-OTULIN antibody [EPR19841]

RabMAb|Recombinant|KO Validated|Trial Size

Immunoprecipitation - Anti-OTULIN antibody [EPR19841] (AB211328)

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  • 0
Biochemicals

AB254528

MLi-2, LRRK2 inhibitor

Chemical Structure - MLi-2, LRRK2 inhibitor (AB254528)

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Primary Antibodies

AB317278

Anti-DKK1 antibody [EPR22363-3] - BSA and Azide free (Detector)

Recombinant|RabMAb

Sandwich ELISA - Anti-DKK1 antibody [EPR22363-3] - BSA and Azide free (Detector) (AB317278)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ZNF592 also known as Zinc Finger Protein 592 is a protein with a molecular mass of approximately 148 kDa. It performs its functions as a transcriptional regulator due to its zinc finger domains which facilitate DNA binding. Researchers have observed its expression across various tissues including the central nervous system where it likely has significant roles due to its regional specificity. By binding to specific DNA sequences ZNF592 regulates the transcription of associated genes influencing cellular processes and development.
Biological function summary

The protein affects neural development and function playing important roles in maintaining the stability of neuron processes. It becomes part of transcriptional regulatory complexes where it interfaces with other proteins to modulate gene expression related to neuronal differentiation. Its activity helps guide the appropriate formation and maintenance of neural networks which are essential for correct brain function. Studies suggest ZNF592 works in regulation with various neuronal transcription factors adding layers of control to the expression pattern of neural genes.

Pathways

ZNF592 has significant contributions to the neurogenesis and neural differentiation pathways where it modulates the expression of key regulatory genes. It operates in relation to pathways involving other important transcription factors like REST (repressor element 1-silencing transcription factor) and soforth ensures the maintenance of neural progenitor cell identity and lineage specification. ZNF592 interacts with these factors to balance cell proliferation and differentiation in the central nervous system.

Mutations or dysregulation of ZNF592 link to neurological conditions such as intellectual disabilities and spinocerebellar ataxia. These conditions reflect the protein’s critical function in neural development and the delicate balance of neuronal cell regulatory mechanisms. In particular ZNF592 associates with the protein Ataxin-1 where they together may contribute to the development of spinocerebellar ataxia type 1 revealing potential pathogenic pathways involving faulty transcriptional regulation in neural tissues. Understanding these connections prompts further research into therapeutic strategies targeting these dysfunctions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May be involved in transcriptional regulation.
See full target information ZNF592
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

HGG advances 6:100391 PubMed39663698

2024

Whole-exome sequencing reveals known and candidate genes for hearing impairment in Mali.

Applications

Unspecified application

Species

Unspecified reactive species

Abdoulaye Yalcouyé,Isabelle Schrauwen,Oumou Traoré,Salia Bamba,Elvis Twumasi Aboagye,Anushree Acharya,Thashi Bharadwaj,Rachel Latanich,Kevin Esoh,Cesar A Fortes-Lima,Carmen de Kock,Mario Jonas,Alassane Dit Baneye Maiga,Cheick A K Cissé,Moussa A Sangaré,Cheick O Guinto,Guida Landouré,Suzanne M Leal,Ambroise Wonkam
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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