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AB241069

Anti-ZNF703 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal ZNF703 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZNF703 aa 100-150.

대체 명칭 보기

ZEPPO1, ZPO1, ZNF703, Zinc finger protein 703, Zinc finger elbow-related proline domain protein 1

2 이미지
Immunoprecipitation - Anti-ZNF703 antibody (AB241069)
  • IP

Supplier Data

Immunoprecipitation - Anti-ZNF703 antibody (AB241069)

ZNF103 was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (1 mg per IP reaction; 20% of IP loaded).

Lane 1 : ab241069 used for IP at 6 μg/mg lysate. For WB 1 μg/ml.
Lane 2 : Control IgG IP.

Chemiluminescence detection : 1 second.

All lanes:

Immunoprecipitation - Anti-ZNF703 antibody (ab241069)

Predicted band size: 58 kDa

false

Western blot - Anti-ZNF703 antibody (AB241069)
  • WB

Supplier Data

Western blot - Anti-ZNF703 antibody (AB241069)

All lanes:

Western blot - Anti-ZNF703 antibody (ab241069) at 0.1 µg/mL

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 2:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Predicted band size: 58 kDa

false

Exposure time: 3s

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human ZNF703 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.

Q9H7S9

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보완 제품

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Antibody was affinity purified using an epitope specific to ZNF703 immobilized on solid support.
보관 버퍼
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ZNF703 also known as Zinc Finger Protein 703 weighs about 62 kDa. This protein functions as a transcription factor playing a significant role in the regulation of gene expression. It mainly localizes to the nucleus where it binds to specific DNA sequences to exert its effects. Reports indicate ZNF703 expression in various tissues such as embryonic stem cells and different cancer types suggesting its importance in development and disease states.
Biological function summary

The involvement of ZNF703 in transcription regulation is critical for cellular processes. Acting as part of the transcriptional repressor complexes ZNF703 interacts with other proteins such as CtBP1 and CtBP2. This interaction results in modulation of the expression of genes that are important for cell cycle progression and developmental pathways. Research highlights its regulatory function in balancing cell proliferation and differentiation impacting both normal and pathological conditions.

Pathways

ZNF703 interacts with several important signaling networks including the E2F and Wnt pathways. Through these interactions ZNF703 influences cell cycle regulation and proliferation. Within these pathways ZNF703 interacts with proteins such as E2F transcription factors and β-catenin which play roles in cell cycle control and developmental processes. These connections illustrate how ZNF703 integrates into a larger cellular network to sustain proper cellular function.

Researchers associate ZNF703 with breast cancer and glioblastoma. Amplification and overexpression of ZNF703 in breast cancer correlate with aggressive tumor phenotypes highlighting its role as an oncogene. ZNF703 also interacts with other cancer-related proteins like MYC enhancing its role in driving tumor progression. Moreover studies indicate ZNF703 overexpression in glioblastoma where it contributes to uncontrolled cell proliferation providing insights into its potential as a therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
See full target information ZNF703
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature cardiovascular research 4:1521-1538 PubMed41039173

2025

ANTXR1 blockade enhances cardiac function in preclinical models of heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Nicola Boccella,GuoJun Yu,Steven Seaman,Yang Feng,Jaewon Lee,Francesco Tomassoni-Ardori,Liping Yang,Kuo-Sheng Hsu,James M Dunleavey,Jodi Becker,Mary Beth Hilton,Karen Morris,Niza Borchin,Daeho So,Pradip Bajgain,Sudhirkumar Yanpallewar,Ryan T Gross,Krish C Dewan,Dawn E Bowles,Darren A Yuen,Lino Tessarollo,Brad St Croix

Cell death & disease 11:225 PubMed32269215

2020

Zinc finger protein 703 induces EMT and sorafenib resistance in hepatocellular carcinoma by transactivating CLDN4 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Wang,Hongfa Xu,Feng Ma,Meixiao Zhan,Xiangyu Yang,Shengni Hua,Wei Li,Yong Li,Ligong Lu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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