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AB223065

Anti-ZnT-7 antibody

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Rabbit Polyclonal ZnT-7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC30A7 aa 150-250.

대체 명칭 보기

ZNT7, ZNTL2, SLC30A7, Zinc transporter 7, ZnT-7, Solute carrier family 30 member 7, Znt-like transporter 2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZnT-7 antibody (AB223065)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZnT-7 antibody (AB223065)

Paraffin-embedded human placental tissue stained for ZnT-7 using ab223065 at 1/100 in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC30A7 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q8NEW0

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보완 제품

Primary Antibodies

AB220725

Anti-K27 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K27 antibody (AB220725)

  • 0
  • 0
Primary Antibodies

AB105194

Anti-ZIP-5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-5 antibody (AB105194)

  • 0
  • 0
Primary Antibodies

AB181537

Anti-Ubiquitin (linkage-specific K27) antibody [EPR17034]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ubiquitin (linkage-specific K27) antibody [EPR17034] (AB181537)

  • 4
  • 1
Primary Antibodies

AB254868

Anti-ZIP-3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-3 antibody (AB254868)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ZnT-7 also known as SLC30A7 is a zinc transporter protein responsible for decreasing cytosolic zinc levels by transporting zinc ions into the Golgi apparatus and trans-Golgi network. The molecular weight of ZnT-7 is approximately 45 kDa. It is expressed in many tissues with high levels found in the liver kidney and heart. The protein is localized mainly in the intracellular membranes playing a role in intracellular zinc homeostasis.
Biological function summary

ZnT-7 participates in the regulation of cellular zinc balance and is important for maintaining optimal enzyme activity and protein function. Although it does not form part of a larger complex itself it interacts with other zinc transporters to help coordinate zinc distribution within cells. This management of zinc levels is important for preventing zinc toxicity and supporting normal cellular activities which are dependent on zinc as a cofactor.

Pathways

ZnT-7 is involved in the zinc homeostasis pathway controlling the intracellular sequestration and distribution of zinc. It works alongside other zinc transporters such as ZnT-1 and ZIP family members to maintain appropriate intracellular zinc levels. ZnT-7 also affects the insulin signaling pathway as zinc ions are modulators of insulin storage and secretion in pancreatic beta cells.

Alterations in ZnT-7 function or expression have been linked to type 2 diabetes and prostate cancer. Disruption of zinc homeostasis due to ZnT-7 malfunction can contribute to metabolic dysfunctions and tumor development. The protein's interaction with other zinc transporters including ZnT-10 highlights its role in these conditions emphasizing the need for proper regulation of zinc levels in disease prevention and management.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed : 15525635, PubMed : 15994300). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed : 15525635, PubMed : 15994300).
See full target information SLC30A7
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 13:7959 PubMed36575174

2022

PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.

Applications

Unspecified application

Species

Unspecified reactive species

Lufei Sui,Suming Wang,Debolina Ganguly,Tyler P El Rayes,Cecilie Askeland,Astrid Børretzen,Danielle Sim,Ole Johan Halvorsen,Gøril Knutsvik,Jarle Arnes,Sura Aziz,Svein Haukaas,William D Foulkes,Diane R Bielenberg,Arturas Ziemys,Vivek Mittal,Rolf A Brekken,Lars A Akslen,Randolph S Watnick
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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