AB171954

Anti-ZP1 antibody [EPR10827]

RabMAb
Recombinant
각 태그의 뜻

(1 리뷰)

(1 출판물)

Rabbit Recombinant Monoclonal ZP1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

1 이미지

Supplier Data

Western blot - Anti-ZP1 antibody [EPR10827] (AB171954)

All lanes:

Western blot - Anti-ZP1 antibody [EPR10827] (ab171954) at 1/1000 dilution

Lane 1:

NIH: OVCAR-3 cell lysate at 10 µg

Lane 2:

SK-OV-3 cell lysate at 10 µg

Lane 3:

LOVO cell lysate at 10 µg

Lane 4:

Human ovary cancer tissue lysate at 10 µg

Predicted band size: 70 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10827

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ZP1 also known as Zona Pellucida Glycoprotein 1 is a protein that plays a mechanical role in the structure of the zona pellucida which is the extracellular matrix surrounding mammalian oocytes. This protein has a molecular mass of approximately 66 kDa. ZP1 is expressed in the ovary particularly by ovarian oocytes. It is one of the critical components that provides structural integrity to the zona pellucida assisting in species-specific sperm binding and initial protection of the oocyte.

Biological function summary

The protein ZP1 facilitates oocyte-sperm interactions during fertilization. It works as part of a complex with other zona pellucida glycoproteins like ZP2 and ZP3. This complex is essential for the cohesion of the zona pellucida enabling its protective and interactive roles. ZP1 helps maintain the mechanical properties of the zona pellucida essential for successful fertilization and eventual embryo development.

Pathways

The protein ZP1 is involved in reproductive pathways particularly those regulating fertilization and early embryonic development. ZP1 interacts closely with ZP2 and ZP3 to form the zona pellucida matrix. This matrix is critical for the sperm binding and zona reaction pathways ensuring only one sperm fertilizes the oocyte. Without the proper function of ZP1 these pathways can be disrupted leading to fertility issues.

Abnormalities in ZP1 can lead to fertilization problems such as infertility or early embryonic loss. Mutations or deficiencies in ZP1 have been associated with conditions like oocyte maturation defects. These defects may connect with alterations in other zona pellucida proteins including ZP2 and ZP3 which can likewise affect fertility. Addressing these disorders often involves understanding the specific roles and interactions of ZP1 with these proteins aiming for potential therapeutic interventions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

See full target information ZP1

대체 명칭 보기

Zona pellucida sperm-binding protein 1, Zona pellucida glycoprotein 1, Zp-1, ZP1

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular medicine 35:1219-29 PubMed25760093

2015

Stem cells derived from human first-trimester umbilical cord have the potential to differentiate into oocyte-like cells in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Hu,Hua Lu,Sheng Cao,Yan-Li Deng,Qi-Jia Li,Qian Wan,Shang-Mian Yie

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZP1 antibody [EPR10827]

Western blot - Anti-ZP1 antibody [EPR10827] (AB171954)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (1)

Product promise