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AB43040

Recombinant Cytomegalovirus Glycoprotein B

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(6 제품이 사용된 논문 )

Recombinant Cytomegalovirus Glycoprotein B is a Human herpesvirus 5 strain AD169 Fragment protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

주요 정보

Purity

>95% SDS-PAGE

Sepharose derived purification.

발현 시스템

Escherichia coli

Tags

Tag free

Applications

ELISA, WB

applications

Biologically active

No

Accession

P06473-1

Animal free

No

Carrier free

No

Species

Human herpesvirus 5 strain AD169

보관 버퍼

pH: 7.2 Constituents: 50% Glycerol (glycerin, glycerine), 0.395% Tris HCl, 0.0292% EDTA

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB116029

Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa) (AB116029)

  • 5
  • 1
Proteins & Peptides

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AB43038

Recombinant Cytomegalovirus pp28 protein

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Recombinant EBV protein

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P06473","tags":[]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.

서열 유사성

Belongs to the herpesviridae glycoprotein B family.

Post-translational modifications

A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.

Subcellular localisation

Host endosome membrane

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제품 프로토콜

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타겟 정보

Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
See full target information gB

대체 명칭 보기

UL55, gB, Envelope glycoprotein B, CMV glycoprotein B, Glycoprotein B, HCMV, HHV5 glycoprotein B, UL55
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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell 186:1417-1431.e20 PubMed37001502

2023

Cytotoxic CD4 T cells eliminate senescent cells by targeting cytomegalovirus antigen.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuya Hasegawa,Tomonori Oka,Heehwa G Son,Valeria S Oliver-García,Marjan Azin,Thomas M Eisenhaure,David J Lieb,Nir Hacohen,Shadmehr Demehri

Nature communications 14:1041 PubMed36823200

2023

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread.

Applications

Unspecified application

Species

Unspecified reactive species

A C Gomes,I A Baraniak,A Lankina,Z Moulder,P Holenya,C Atkinson,G Tang,T Mahungu,F Kern,P D Griffiths,M B Reeves

Frontiers in immunology 13:1083230 PubMed36591233

2022

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites.

Applications

Unspecified application

Species

Unspecified reactive species

Emma L Davies,Mahlaqua Noor,Eleanor Y Lim,Charlotte J Houldcroft,Georgina Okecha,Claire Atkinson,Matthew B Reeves,Sarah E Jackson,Mark R Wills

PLoS pathogens 15:e1008064 PubMed31841557

2019

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody.

Applications

Unspecified application

Species

Unspecified reactive species

Simone I Richardson,Bronwen E Lambson,Andrew R Crowley,Arman Bashirova,Cathrine Scheepers,Nigel Garrett,Salim Abdool Karim,Nonhlanhla N Mkhize,Mary Carrington,Margaret E Ackerman,Penny L Moore,Lynn Morris

Journal of pharmaceutical and biomedical analysis 156:372-378 PubMed29758495

2018

A rapid magnetic particle-based enzyme immunoassay for human cytomegalovirus glycoprotein B quantification.

Applications

Unspecified application

Species

Unspecified reactive species

F Pires,M Julia Arcos-Martinez,A Cristina Dias-Cabral,Juan C Vidal,Juan R Castillo

Scientific reports 7:937 PubMed28428537

2017

Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice.

Applications

ELISA

Species

Unspecified reactive species

Lindsey B Crawford,Rebecca Tempel,Daniel N Streblow,Craig Kreklywich,Patricia Smith,Louis J Picker,Jay A Nelson,Patrizia Caposio
제품이 사용된 논문 모두 보기
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Product promise

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