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AB238375

Recombinant E. coli fimH protein (His tag)

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Recombinant E. coli fimH protein (His tag) is a Escherichia coli (strain K12) Full Length protein, in the 22 to 300 aa range, expressed in Yeast, with >90% purity and suitable for SDS-PAGE. The predicted molecular weight of ab238375 protein is 31.1 kDa.

- Save time and ensure accurate results - use our E. coli Type 1 fimbrin D-mannose specific adhesin (FimH) protein as a control

대체 명칭 보기

b4320, JW4283, fimH, Type 1 fimbrin D-mannose specific adhesin, Protein FimH

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SDS-PAGE - Recombinant E. coli fimH protein (His tag) (AB238375)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant E. coli fimH protein (His tag) (AB238375)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab238375.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Escherichia coli K-12

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB116028

Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa) (AB116028)

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Recombinant E. coli FimA protein (His tag)

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Recombinant Human C4 protein

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AB318256

Recombinant Clostridioides difficile Toxin B/TcdB Protein (His-tag)

Mass Spectrometry - Recombinant Clostridioides difficile Toxin B/TcdB Protein (His-tag) (AB318256)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Ensure the validity of your result using our recombinant E. coli Type 1 fimbrin D-mannose specific adhesin (FimH) protein ab238375 as a positive control in SDS-PAGE.


Check out our protein gel staining guide for SDS-PAGE here
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서열 정보

[{"linker":null,"sequence":"FACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ","proteinLength":"Full Length","predictedMolecularWeight":"31.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":300,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"P08191","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The fimH protein also known as FimH adhesin or fimbrial protein serves as an essential adhesion factor in bacteria. With a molecular weight of approximately 29 kDa it is part of the type 1 fimbriae complex and gets highly expressed in Escherichia coli (E. coli). FimH facilitates the attachment of bacteria to host cells by recognizing and binding to mannose residues on the host's surface. This binding is important for the initial colonization and establishment of bacterial infections.
Biological function summary

The fimH protein plays a significant role in E. coli pathogenicity. It acts as part of the type 1 pili enabling the organism to attach firmly to uroepithelial cells and promoting urinary tract infections. As an important component of the fimbrial complex FimH combines with other pilus proteins to create a structure that extends from the bacterial cell surface. This facilitates the evasion of host immune responses and contributes to bacterial virulence.

Pathways

The fimH protein is integral to bacterial adherence and colonization pathways. It interacts with mannose-containing glycoproteins on the host cell surface which is important for the bacterial invasion pathway. FimH association with its pilus subunits like FimC is pivotal for pilus assembly and stability. The protein's role in these pathways highlights its involvement in infections particularly urinary tract infections (UTIs).

The fimH protein holds a strong connection to urinary tract infections and gastrointestinal diseases due to its adhesive capabilities. The protein enables E. coli to attach to and invade host tissues leading to infections. Additionally FimH interacts with the host's uroplakin proteins which are implicated in the bladder epithelium's defense mechanisms. This interaction highlights FimH's contribution to the pathogenic potential of E. coli during bladder infections.
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일반 정보

기능

Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.

서열 유사성

Belongs to the fimbrial protein family.

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제품 프로토콜

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타겟 정보

Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
See full target information fimH
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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