Recombinant E. coli Trigger factor (tig) protein (His tag)

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Biological function summary

Trigger factor prevents aggregation and misfolding of newly synthesized proteins. It plays a significant role in the initial stages of protein folding. It does not operate as part of a multi-protein complex but can function independently or in coordination with other chaperones like DnaK enhancing the overall protein folding capacity within cells. The presence of trigger factor regulates the equilibrium between folding competent and non-competent polypeptides supporting cellular protein quality control.

Pathways

Trigger factor contributes to protein homeostasis and is integral in the protein quality control pathway. This pathway ensures proper folding and functionality of proteins reducing the occurrence of dysfunctional proteins that could lead to cellular stress. Related proteins include DnaK and GroEL which also participate in the unfolded protein response. These proteins collectively maintain proteostasis by managing misfolded proteins and facilitating proper protein folding.