Recombinant EBV Latent Membrane Protein 1 (His tag)
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Recombinant EBV Latent Membrane Protein 1 (His tag) is a Epstein-Barr virus Fragment protein, in the 185 to 366 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE, Mass Spec.
대체 명칭 보기
BNLF1, LMP1, Latent membrane protein 1, LMP-1, Protein p63, BNLF1, EBV, Epstein Barr virus, HHV4, Human Herpesvirus 4, Latent membrane protein 1
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant EBV Latent Membrane Protein 1 (His tag) (AB240835)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS analysis result of ab240835 could indicate that this peptide derived from Yeast-expressed Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) EBV Latent Membrane Protein 1.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant EBV Latent Membrane Protein 1 (His tag) (AB240835)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS analysis result of ab240835 could indicate that this peptide derived from Yeast-expressed Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) EBV Latent Membrane Protein 1.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant EBV Latent Membrane Protein 1 (His tag) (AB240835)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab240835.
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein plays a role in cellular transformation and proliferation acting as a mimic of CD40 receptor signaling. Within cells LMP1 aggregates to form oligomeric complexes that actively recruit TRAF and TRADD adapter proteins. This aggregation leads to the activation of NF-κB signaling and the MAPK pathways contributing to increased cell survival and proliferation. LMP1 functions as a major factor in sustaining EBV latency in infected cells and is essential for the virus's oncogenic potential.
Pathways
LMP1 is an integral component of the NF-κB and AP-1 signaling pathways. By engaging with the host cell machinery LMP1 recruits proteins such as IκB kinase complexes leading to the nuclear translocation of NF-κB transcription factors. This results in the transcription of genes related to cell growth and inflammation. LMP1 also interacts with p38 MAPK further enhancing pathways that contribute to EBV’s ability to foster an environment suitable for its persistence and propagation within the host.
일반 정보
기능
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses. Also inhibits host IFN-alpha-stimulated STAT2 nuclear translocation and interferon-stimulated response element transcriptional activity by interacting with and inhibiting host TYK2. Induces SUMO expression during viral latency thereby dysregulating the host sumoylation processes.
서열 유사성
Belongs to the herpesviridae LMP-1 family.
Post-translational modifications
Ubiquitinated on the N-terminus.
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