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AB49034

Recombinant Hepatitis E Virus ORF3 antigen protein (Tag Free)

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Recombinant Hepatitis E Virus ORF3 antigen protein (Tag Free) is a Hepatitis E virus isolate Hetian protein, in the 92 to 123 aa range, expressed in Escherichia coli, with >95%.

주요 정보

Purity

>95% SDS-PAGE

발현 시스템

Escherichia coli

Tags

Tag free

Biologically active

No

Accession

Q81870-1

Animal free

No

Carrier free

No

Species

Hepatitis E virus isolate Hetian

보관 버퍼

pH: 7.2 - 7.6 Constituents: 48% Urea, 0.316% Tris HCl, 0.078% 2-Mercaptoethanol

storage-buffer

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보완 제품

Primary Antibodies

AB233244

Anti-Hepatitis E Virus antibody [5F3]

Immunocytochemistry/ Immunofluorescence - Anti-Hepatitis E Virus antibody [5F3] (AB233244)

  • 0
  • 0
Proteins & Peptides

AB49036

Recombinant Hepatitis E Virus ORF2 antigen protein (Tag Free)

  • 0
  • 0
Proteins & Peptides

AB49013

Recombinant Hepatitis B Virus Core Antigen protein (Tag Free)

  • 0
  • 0
Secondary Antibodies

AB97240

Goat Anti-Mouse IgG1 (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Mouse IgG1 (HRP) (AB97240)

  • 5
  • 1
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서열 정보

[{"linker":null,"sequence":"NPPDHSAPLGVTRPSAPPLPHVVDLPQLGPRR","proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":123,"aminoAcidStart":92,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q81870","tags":[]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis E Virus ORF3 antigen also called HEV ORF3 protein is significant in virus lifecycle and pathogenicity. This protein has an approximate mass of 13 kDa and is expressed during the infection in the liver. HEV ORF3 plays a pivotal role in viral replication and pathogenesis by mediating particle secretion and modulating host cell signaling pathways ensuring the successful release of the virus.
Biological function summary

The HEV ORF3 protein supports virus egress and interacts with multiple host cellular factors. It does not form part of a larger protein complex but serves itself as a multifunctional element. ORF3 facilitates the transportation of viral particles through the modulation of host cell processes enhancing viral propagation and persistence. This small protein significantly affects the host's cellular environment to enable the virus's survival and spread.

Pathways

HEV ORF3 interacts with and alters host antiviral pathways such as the interferon signaling pathway and the phosphatidylinositol pathway. Through these interactions it disrupts the innate immune response aiding in immune evasion. This enables the virus to persist by weakening the host defenses and cooperating with viral proteins to enhance the success of the infection.

HEV ORF3 is directly associated with hepatitis E a liver disease caused by the hepatitis E virus. The protein's manipulation of host immune responses correlates with the disease's pathology often leading to hepatic complications during infection. While not extensively studied in connection to other specific diseases it potentially impacts related proteins through shared viral mechanisms and immune evasion strategies.
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일반 정보

기능

Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity (PubMed : 19339479, PubMed : 21068219, PubMed : 28096411, PubMed : 30532200). Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway (PubMed : 19339479, PubMed : 21068219). Also acts as a viroporin and forms ion conductive pores allowing viral particle release (PubMed : 28096411). Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways (PubMed : 27270888, PubMed : 29872132). Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression (PubMed : 26492885). Interacts with host microtubules (PubMed : 19369329).

서열 유사성

Belongs to the hepevirus ORF3 protein family.

Post-translational modifications

Palmitoylated in the N-terminus.

Subcellular localisation

Host cytoskeleton

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제품 프로토콜

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타겟 정보

Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity (PubMed : 19339479, PubMed : 21068219, PubMed : 28096411, PubMed : 30532200). Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway (PubMed : 19339479, PubMed : 21068219). Also acts as a viroporin and forms ion conductive pores allowing viral particle release (PubMed : 28096411). Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways (PubMed : 27270888, PubMed : 29872132). Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression (PubMed : 26492885). Interacts with host microtubules (PubMed : 19369329).
See full target information ORF3

대체 명칭 보기

Protein ORF3, pORF3, Vp13, ORF3, HEV ORF3, Hepatitis E Virus ORF3
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Product promise

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