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AB238369

Recombinant HPV18 E7 protein (His tag)

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Recombinant HPV18 E7 protein (His tag) is a Human papillomavirus type 18 Full Length protein, in the 1 to 105 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

Protein E7, E7, E7 protein, Human Papilloma Virus Type 18 E7 protein

1 이미지
SDS-PAGE - Recombinant HPV18 E7 protein (His tag) (AB238369)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant HPV18 E7 protein (His tag) (AB238369)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab238369.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human papillomavirus type 18

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB234592

Prestained Protein Ladder - Extra broad molecular weight (6.5 - 270 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (6.5 - 270 kDa) (AB234592)

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Proteins & Peptides

AB226447

Recombinant HPV16 E6 protein (His tag)

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Proteins & Peptides

AB119880

Recombinant HPV16 L1 protein

Electron Microscopy - Recombinant HPV16 L1 protein (AB119880)

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Primary Antibodies

AB308296

Anti-HPV18 E7 antibody [EPR26911-29]

20ul selling size|RabMAb|Recombinant|Trial Size

Flow Cytometry (Intracellular) - Anti-HPV18 E7 antibody [EPR26911-29] (AB308296)

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Proteins & Peptides

AB224863

Recombinant Human herpesvirus EBV Early Antigen Restricted Ea-R p85 protein (His tag)

SDS-PAGE - Recombinant Human herpesvirus EBV Early Antigen Restricted Ea-R p85 protein (His tag) (AB224863)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIKLVVESSADDLRAFQQLFLNTLSFVCPWCASQQ","proteinLength":"Full Length","predictedMolecularWeight":"12 kDa","actualMolecularWeight":null,"aminoAcidEnd":105,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"P06788","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed : 26405230).

서열 유사성

Belongs to the papillomaviridae E7 protein family.

Post-translational modifications

Highly phosphorylated.

Subcellular localisation

Host nucleus

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제품 프로토콜

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타겟 정보

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed : 26405230).
See full target information E7
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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