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AB134548

Recombinant Human ABI3 protein (denatured) (His tag N-Terminus)

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Recombinant Human ABI3 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 366 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

NESH, ABI3, ABI gene family member 3, New molecule including SH3, Nesh

1 이미지
SDS-PAGE - Recombinant Human ABI3 protein (denatured) (His tag N-Terminus) (AB134548)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ABI3 protein (denatured) (His tag N-Terminus) (AB134548)

15% SDS-PAGE analysis of 3μg ab134548.

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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보완 제품

Primary Antibodies

AB214318

Anti-ABI3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABI3 antibody (AB214318)

  • 3
  • 1
Primary Antibodies

AB278054

Anti-GFAP antibody [RM1003] - Astrocyte Marker

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody [RM1003] - Astrocyte Marker (AB278054)

  • 0
  • 0
Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 75
Primary Antibodies

AB178846

Anti-Iba1 antibody [EPR16588] - Microglia marker

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Iba1 antibody [EPR16588] - Microglia marker (AB178846)

  • 5
  • 50
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALASVAYQVGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPPGQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDLSTQLSRTGTLSRKSIKAPATPASATLGRPPRIPEPVHLPVVPDGRLSAASSASSLASAGSAEGVGGAPTPKGQAAPPAPPLPSSLDPPPPPAAVEVFQRPPTLEELSPPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVEPSC","proteinLength":"Full Length","predictedMolecularWeight":"41.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":366,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9P2A4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ABI3 also known as the ATP-binding cassette sub-family I member 3 is a protein involved in lipid transport and metabolism. It weighs approximately 34 kDa. This protein is expressed in various tissues most notably in the brain and immune cells. The presence of ABI3 has been noted in microglia which are the brain’s resident macrophages highlighting its significance in central nervous system functioning.
Biological function summary

The protein ABI3 plays an essential role in phagocytic activity which helps in clearing cellular debris and toxins supporting immune response and maintenance of tissue homeostasis. ABI3 integrates into a larger macromolecular complex where it interacts with other proteins to influence phagocytosis efficiency. Such interactions empower ABI3 to modulate inflammatory responses thereby contributing to cellular defense mechanisms.

Pathways

Different cellular processes involve ABI3 especially the PI3K-Akt pathway and the immune response pathways. The PI3K-Akt pathway is critical for cell survival and growth where ABI3 modulates these activities. ABI3 interacts with other proteins in this pathway like AKT1 to impact cellular metabolism and survival decisions. Furthermore its involvement in immune response pathways highlights its role in maintaining cellular health through modulating both inflammation and phagocytosis.

ABI3 has associations with neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. Its role in affected microglial function directly links to inflammatory processes observed in these conditions. Additionally ABI3 interacts with proteins like TREM2 in microglial cells which research connects to Alzheimer’s disease offering insights into potential therapeutic targets.
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일반 정보

기능

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.

서열 유사성

Belongs to the ABI family.

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제품 프로토콜

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타겟 정보

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
See full target information ABI3
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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