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AB207118

Recombinant Human ACSF2 protein (His tag N-Terminus)

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Recombinant Human ACSF2 protein (His tag N-Terminus) is a Human Full Length protein, in the 42 to 615 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

대체 명칭 보기

UNQ493/PRO1009, ACSF2

1 이미지
SDS-PAGE - Recombinant Human ACSF2 protein (His tag N-Terminus) (AB207118)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ACSF2 protein (His tag N-Terminus) (AB207118)

15% SDS-PAGE (ab207118 used at 3 μg)

주요 정보

Purity

>95% SDS-PAGE

ab207118 was purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSLSSREVDRMVSTPIGGLSYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLNL","proteinLength":"Full Length","predictedMolecularWeight":"66.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":615,"aminoAcidStart":42,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96CM8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ACSF2 also known as acyl-CoA synthetase family member 2 is a unique enzyme responsible for the activation of medium-chain fatty acids through the formation of acyl-CoA. This process is critical for fatty acid metabolism energy production and various biosynthetic pathways. ACSF2 has a molecular mass of approximately 68 kDa. The enzyme is widely expressed in human tissues with notable expression seen in liver and heart which suggests its importance in energy metabolism associated with these organs.
Biological function summary

Acyl-CoA synthetase family member 2 participates in the conversion of fatty acids to acyl-CoA a fundamental step in lipid metabolism. ACSF2 operates independently not currently identified as part of a complex. However its role is important in maintaining the acyl-CoA pool in the cellular environment therefore influencing lipid biosynthesis and degradation processes and enabling the efficient use of fatty acids for energy.

Pathways

The enzyme acyl-CoA synthetase family member 2 is involved in the fatty acid metabolism and beta-oxidation pathways. These are essential for energy production especially in tissues with high metabolic rates like liver and muscle. ACSF2's function impacts how cells convert fatty acids into energy. The protein interacts with other enzymes in these pathways such as carnitine palmitoyltransferase (CPT) which is involved in transporting fatty acids into mitochondria for breakdown.

Dysfunctional ACSF2 links to rare metabolic disorders affecting lipid processing. Defects in this enzyme could contribute to conditions such as non-alcoholic fatty liver disease or certain forms of cardiomyopathy. Through these disorders ACSF2 indirectly connects with proteins involved in lipid accumulation and energy regulation like fatty acid-binding proteins (FABPs) which play roles in the cellular handling of fatty acids. Understanding ACSF2's function could therefore offer insights for therapeutic strategies targeting lipid metabolism disorders.

일반 정보

기능

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed : 17762044). Has some preference toward medium-chain substrates (PubMed : 17762044). Plays a role in adipocyte differentiation (PubMed : 16380219).

서열 유사성

Belongs to the ATP-dependent AMP-binding enzyme family.

제품 프로토콜

타겟 정보

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed : 17762044). Has some preference toward medium-chain substrates (PubMed : 17762044). Plays a role in adipocyte differentiation (PubMed : 16380219).
See full target information ACSF2

Product promise

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