JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB289753

Recombinant Human ADTRP protein

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human ADTRP protein is a Human Full Length protein, in the 1 to 230 aa range, expressed in Cell free, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

C6orf105, ADTRP, Androgen-dependent TFPI-regulating protein, Fatty acid esters of hydroxy fatty acids hydrolase ADTRP, FAHFA hydrolase ADTRP

1 이미지
SDS-PAGE - Recombinant Human ADTRP protein (AB289753)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ADTRP protein (AB289753)

SDS-PAGE analysis of ab289753

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Cell free

Tags

10x His tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

Yes

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol

storage-buffer

style
left-column

보완 제품

Proteins & Peptides

AB43041

Recombinant Cytomegalovirus pp65 protein

  • 0
  • 0
Proteins & Peptides

AB87412

Recombinant Human GMFG protein (Tag Free)

SDS-PAGE - Recombinant Human GMFG protein (Tag Free) (AB87412)

  • 0
  • 0
Proteins & Peptides

AB167835

Recombinant Human CAMLG/CAML protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human CAMLG/CAML protein (His tag N-Terminus) (AB167835)

  • 0
  • 0
Primary Antibodies

AB178867

Anti-p38 (phospho T180) antibody [EPR16587]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-p38 (phospho T180) antibody [EPR16587] (AB178867)

  • 5
  • 2
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

서열 정보

[{"linker":null,"sequence":"MTKTSTCIYHFLVLSWYTFLNYYISQEGKDEVKPKILANGARWKYMTLLNLLLQTIFYGVTCLDDVLKRTKGGKDIKFLTAFRDLLFTTLAFPVSTFVFLAFWILFLYNRDLIYPKVLDTVIPVWLNHAMHTFIFPITLAEVVLRPHSYPSKKTGLTLLAAASIAYISRILWLYFETGTWVYPVFAKLSLLGLAAFFSLSYVFIASIYLLGEKLNHWKWGDMRQPRKKRK","proteinLength":"Full Length","predictedMolecularWeight":"31.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":230,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q96IZ2","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
style
left-column

특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ADTRP also known as androgen-dependent TFPI-regulating protein is a protein with a molecular mass of approximately 24 kDa. This protein is expressed in several tissues notably in human endothelium and heart. Mechanically ADTRP acts by modulating the activity of tissue factor pathway inhibitor (TFPI) which plays an important role in blood coagulation regulation. By influencing TFPI ADTRP controls hemostatic balance affecting both coagulation and fibrinolysis processes.
Biological function summary

This protein is involved in maintaining vascular homeostasis. ADTRP does not act alone; it participates as part of a larger regulatory network impacting TFPI and coagulation pathways. The modulation of TFPI by ADTRP affects thrombin generation demonstrating its biological significance in controlling excessive blood clot formation therefore ensuring proper circulatory function and blood fluidity.

Pathways

The activity of ADTRP is integral to the blood coagulation cascade. It connects closely with the extrinsic pathway of coagulation where it regulates the inhibitory action of TFPI on the factor Xa and thrombin generation. Another connection is with the fibrinolytic system where ADTRP influences the balance between clot formation and breakdown a critical aspect of vascular health.

ADTRP has implications in conditions like coronary artery disease and pulmonary embolism. Alterations in ADTRP's function can influence the balance between coagulation and anticoagulation impacting disease progression. As part of its role ADTRP is associated with other proteins involved in the coagulation pathway such as TFPI which is known to be a significant player in thrombotic conditions. Understanding how ADTRP connects to these diseases may offer pathways for therapeutic interventions.
style
left-column

일반 정보

기능

Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed : 27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed : 27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed : 21868574).

서열 유사성

Belongs to the AIG1 family.

style
left-column

제품 프로토콜

style
left-column

타겟 정보

Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed : 27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed : 27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed : 21868574).
See full target information ADTRP
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com