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AB113593

Recombinant Human AK5 protein (His tag N-Terminus)

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Recombinant Human AK5 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 562 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

Adenylate kinase isoenzyme 5, AK 5, ATP-AMP transphosphorylase 5, AK5

1 이미지
SDS-PAGE - Recombinant Human AK5 protein (His tag N-Terminus) (AB113593)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human AK5 protein (His tag N-Terminus) (AB113593)

15% SDS-PAGE analysis of ab113593 (3μg)

주요 정보

Purity

>85% SDS-PAGE

ab113593 was purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Biochemicals

AB144614

HPI-1, hedgehog signaling inhibitor

Chemical Structure - HPI-1, hedgehog signaling inhibitor (AB144614)

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Proteins & Peptides

AB134607

Recombinant Human C1orf33 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human C1orf33 protein (His tag N-Terminus) (AB134607)

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Primary Antibodies

AB117927

Anti-AK5 antibody [OTI1D6]

Flow Cytometry - Anti-AK5 antibody [OTI1D6] (AB117927)

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Proteins & Peptides

AB202261

Recombinant Human SH3GL3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human SH3GL3 protein (His tag N-Terminus) (AB202261)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMNTNDAKEYMARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPGNSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIF","proteinLength":"Full Length","predictedMolecularWeight":"65.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":562,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y6K8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

AK5 or Adenylate Kinase 5 is an enzyme with a specialized role in phosphate group transfer. It functions by catalyzing the reversible transfer of phosphate groups from ATP to AMP which results in the production of ADP. The enzyme has a molecular mass of approximately 26 kDa. AK5 typically shows expression in the brain where it can significantly influence energy transfer and cellular energy balance.
Biological function summary

The function of AK5 involves maintaining energy homeostasis in neural cells. It does not act independently; rather it functions as a part of a larger complex that regulates cellular energetic states. In neural tissues AK5 may have substantial impacts on cellular activity by controlling the levels of key adenylates therefore influencing intracellular signaling pathways.

Pathways

AK5 plays a part in the cellular energy homeostasis pathway and is integral to the purine metabolism pathway. In these pathways AK5 interacts with other adenylate kinases and has associations with enzymes such as AMP-activated protein kinase (AMPK) which acts as an energy sensor. AK5's role in these pathways helps to maintain the balance of adenine nucleotides critical for cellular functions.

Abnormalities in AK5 expression or function can be associated with neurological conditions such as epilepsy. AK5's connection with epilepsy relates partly through its involvement in maintaining proper cellular energetic conditions critical for normal neural activity. It may also relate to metabolic disorders because changes in adenylate kinase function can impact metabolic regulation in the brain. AK5's relationship with AMPK hints at how it might link to these conditions given AMPK's role in detecting cellular energy levels.
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일반 정보

기능

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

서열 유사성

Belongs to the adenylate kinase family.

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제품 프로토콜

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타겟 정보

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.
See full target information Adenylate kinase isoenzyme 5
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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