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AB222356

Recombinant Human Aldolase C protein (Tag Free)

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Recombinant Human Aldolase C protein (Tag Free) is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

ALDC, ALDOC, Fructose-bisphosphate aldolase C, Brain-type aldolase

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SDS-PAGE - Recombinant Human Aldolase C protein (Tag Free) (AB222356)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Aldolase C protein (Tag Free) (AB222356)

Recombinant human Aldolase C (3μg) analysed by 15% SDS-PAGE.

주요 정보

Purity

>90% SDS-PAGE

Purified by conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

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Primary Antibodies

AB302952

Anti-Aldolase C - N-terminal antibody [EPR26895-52]

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Immunohistochemistry - Anti-Aldolase C - N-terminal antibody [EPR26895-52] (AB302952)

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AB124563

Recombinant Human NAGK protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human NAGK protein (His tag N-Terminus) (AB124563)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGIVVGIKVDKGVVPLAGTDGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPSALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACPIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASFNLNAINRCPLPRPWALTFSYGRALQASALNAWRGQRDNAGAATEEFIKRAEVNGLAAQGKYEGSGEDGGAAAQSLYIANHAY","proteinLength":"Full Length","predictedMolecularWeight":"39.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":364,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P09972","tags":[]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Aldolase C also known as ALDOC is an enzyme that plays an important role in glycolysis. It catalyzes the reversible conversion of fructose-16-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. Aldolase C has a molecular mass of approximately 39 kDa. This enzyme is primarily expressed in the brain particularly in astrocytes where it serves as an identifier for these cells.
Biological function summary

This enzyme contributes to energy metabolism within cells notably astrocytes. It is part of the aldolase family which includes isoenzymes like aldolase A and B that perform similar functions in different tissues. Aldolase C is involved in maintaining glucose homeostasis and energy production in the brain where it forms part of a complex with other glycolytic enzymes to facilitate efficient cellular respiration.

Pathways

Aldolase C is a significant component of the glycolytic pathway facilitating energy production in cells. It plays alongside other glycolytic enzymes such as hexokinase phosphofructokinase and pyruvate kinase to convert glucose into pyruvate transferring energy in the process. Additionally aldolase C participates in the fructose metabolism pathway similar to its isoenzymes aiding in the conversion of fructose derivatives important for maintaining normal energy levels in brain tissues.

Aldolase C has connections to neurological conditions like glioma and neurodegenerative diseases. Altered expression levels of aldolase C can indicate glioma progression or serve as a biomarker in astrocytic neurodegenerative disorders. The enzyme’s function is also linked to its interaction with other proteins such as Glial Fibrillary Acidic Protein (GFAP) in astrocytes which assist in maintaining normal cell structure and response to damage. Therefore aldolase C serves both as a metabolic enzyme and a potential marker in assessing neurological health and disease.
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일반 정보

기능

Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis.

서열 유사성

Belongs to the class I fructose-bisphosphate aldolase family.

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제품 프로토콜

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타겟 정보

Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis.
See full target information ALDOC
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Product promise

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