Recombinant Human ALK-7 protein (Fc Chimera) is a Human Fragment protein, in the 1 to 113 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
대체 명칭 보기
ALK7, ACVR1C, Activin receptor type-1C, Activin receptor type IC, Activin receptor-like kinase 7, ACTR-IC, ALK-7
- SDS-PAGE
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SDS-PAGE - Recombinant Human ALK-7 protein (Fc Chimera) (AB276329)
SDS-PAGE analysis of ab276329
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ALK-7 participates in the regulation of metabolic processes. It functions by forming a receptor complex with type II receptors upon ligand binding transmitting signals that modulate cellular responses. ALK-7's signaling is important in maintaining glucose homeostasis and energy balance within tissues. Additionally the activity of ALK-7 influences the differentiation of neural cells and the development of adipose tissue illustrating its multifaceted biological roles.
Pathways
The signaling of ALK-7 integrates into the TGF-beta/Activin signaling pathway and the Nodal signaling pathway. Within these pathways it associates functionally with proteins such as SMAD2/3 which facilitate the transmission of extracellular signals to the nucleus resulting in gene expression changes. These pathways are significant for developmental processes and cellular metabolism regulation where ALK-7 contributes to signal transduction necessary for physiological adaptations.
일반 정보
기능
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed : 15531507, PubMed : 15150278). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (By similarity).
서열 유사성
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
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