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AB157870

Recombinant Human Angiotensin II Type 1 Receptor protein (GST tag N-Terminus)

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Recombinant Human Angiotensin II Type 1 Receptor protein (GST tag N-Terminus) is a Human Fragment protein, in the 250 to 359 aa range, expressed in Wheat germ, suitable for ELISA, WB.
1 이미지
SDS-PAGE - Recombinant Human Angiotensin II Type 1 Receptor protein (GST tag N-Terminus) (AB157870)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Angiotensin II Type 1 Receptor protein (GST tag N-Terminus) (AB157870)

ab157870 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P30556-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

  • 0
  • 0
Proteins & Peptides

AB316476

Recombinant Human ACE Protein Standard (His tag)

Sandwich ELISA - Recombinant Human ACE Protein Standard (His tag) (AB316476)

  • 0
  • 0
Proteins & Peptides

AB271638

Recombinant human NNMT protein (Active) (His tag C-Terminus)

Functional Studies - Recombinant human NNMT protein (Active) (His tag C-Terminus) (AB271638)

  • 0
  • 0
Primary Antibodies

AB124734

Anti-Angiotensin II Type 1 Receptor antibody [EPR3873]

20ul selling size|RabMAb|Recombinant

Indirect ELISA - Anti-Angiotensin II Type 1 Receptor antibody [EPR3873] (AB124734)

  • 2
  • 1
Primary Antibodies

AB119758

Anti-NNMT antibody [OTI3D8]

KO Validated

Western blot - Anti-NNMT antibody [OTI3D8] (AB119758)

  • 5
  • 3
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"FFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRHSDNVSSSTKKPAPCFEVE","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":359,"aminoAcidStart":250,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P30556","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Angiotensin II Type 1 Receptor also known as AGTR1 AT1 receptor or Angiotensin Receptor 1 is a G protein-coupled receptor with a mass of approximately 45 kDa. This receptor binds to the angiotensin II peptide playing a central role in regulating blood pressure. It is broadly expressed in tissues such as vascular smooth muscle cells cardiac myocytes kidneys and brain. The AT1 receptor mediates vasoconstriction aldosterone secretion and cellular growth through its interaction with angiotensin II impacting cardiovascular functions.
Biological function summary

The Angiotensin II Type 1 Receptor contributes significantly to the regulation of cardiovascular homeostasis. It forms part of a complex signaling system involving G proteins phospholipase C and other downstream effectors. This receptor elicits responses important for maintaining vascular tone and fluid balance. By activating intracellular signaling cascade it plays an essential role in sodium reabsorption and systemic blood pressure maintenance. The receptor's expression and activity represent an important component in cardiovascular function.

Pathways

The AT1 receptor participates actively in the renin-angiotensin system (RAS) and is a significant player in the regulation of blood pressure. It interacts with angiotensin converting enzyme (ACE) and angiotensin II within this pathway. Additionally the receptor is linked to the mitogen-activated protein kinase (MAPK) pathway which further influences cell proliferation and vascular remodeling. These interactions highlight the receptor's involvement in vascular smooth muscle cell function and the broader implications for cardiovascular health.

The Angiotensin II Type 1 Receptor is closely associated with conditions such as hypertension and heart failure. Dysfunction or overactivity of this receptor contributes to elevated blood pressure and compromised cardiac function. The AT1 receptor's connection to ACE highlights its therapeutic relevance as many antihypertensive treatments target this interaction. By modulating the receptor's activity these treatments aim to alleviate symptoms and reduce the risk of cardiovascular events.
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제품 프로토콜

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타겟 정보

Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed : 15611106, PubMed : 1567413, PubMed : 25913193, PubMed : 26420482, PubMed : 30639100, PubMed : 32079768, PubMed : 8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed : 15611106).. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
See full target information AGTR1

대체 명칭 보기

AGTR1A, AGTR1B, AT2R1, AT2R1B, AGTR1, Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1 receptor
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록and refine your search

American journal of physiology. Renal physiology 313:F440-F449 PubMed28468964

2017

Luminal ANG II is internalized as a complex with ATR/ATR heterodimers to target endoplasmic reticulum in LLC-PK cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fernanda M Ferrão,Luiza H D Cardoso,Heather A Drummond,Xiao C Li,Jia L Zhuo,Dayene S Gomes,Lucienne S Lara,Adalberto Vieyra,Jennifer Lowe
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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