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AB113118

Recombinant Human ARL15 protein (His tag N-Terminus)

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(1 출판물)

Recombinant Human ARL15 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 204 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

ARFRP2, ARL15, ADP-ribosylation factor-like protein 15, ADP-ribosylation factor-related protein 2, ARF-related protein 2

1 이미지
SDS-PAGE - Recombinant Human ARL15 protein (His tag N-Terminus) (AB113118)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ARL15 protein (His tag N-Terminus) (AB113118)

15% SDS-PAGE analysis of 3 µg ab113118.

주요 정보

Purity

>85% SDS-PAGE

ab113118 is purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Primary Antibodies

AB178425

Anti-ARL15 antibody [EPR12591]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-ARL15 antibody [EPR12591] (AB178425)

  • 0
  • 0
Primary Antibodies

AB209490

Anti-Desmoglein 1/DSG1 antibody [EPR20382]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 1/DSG1 antibody [EPR20382] (AB209490)

  • 0
  • 0
Primary Antibodies

AB188865

Anti-TXNIP antibody [EPR14774]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNIP antibody [EPR14774] (AB188865)

  • 4
  • 4
Primary Antibodies

AB109725

Anti-Cytokeratin 17 antibody [EP1623] - Cytoskeleton Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Cytokeratin 17 antibody [EP1623] - Cytoskeleton Marker (AB109725)

  • 3
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDNVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEIKKYFELEPLARGKRWILQPCSLDDMDALKDSFSQLINLLEEKDHEAVRM","proteinLength":"Full Length","predictedMolecularWeight":"25 kDa","actualMolecularWeight":null,"aminoAcidEnd":204,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NXU5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ARL15 also known as ADP-ribosylation factor-like protein 15 is a member of the ARF family of GTPases. This small GTP-binding protein weighs about 21 kDa. ARL15 resides mainly in the cytoplasm but its expression is also notable in adipose tissue and the pancreas. Mechanical interaction of ARL15 with membranes and other molecules is characteristic for proteins in the ARF family indicating a role in cellular functions that involve vesicle trafficking or membrane remodeling.
Biological function summary

ARL15 influences metabolic processes and signaling pathways. It integrates into multiprotein complexes that regulate various cellular activities. Research suggests its involvement in lipid metabolism and adipogenesis playing a role in the regulation of insulin sensitivity. These biological functions make ARL15 significant for maintaining cellular energy balance and metabolic homeostasis.

Pathways

ARL15 engages with two central pathways: the insulin signaling pathway and lipid metabolism. It influences these pathways by interacting with key proteins such as IRS1 in insulin signaling which impacts glucose uptake and energy regulation. Additionally in lipid metabolism ARL15 associates with proteins that control fatty acid oxidation and storage contributing to the overall lipid balance within the cell.

ARL15 has connections to type 2 diabetes and obesity. People with altered expression levels of ARL15 often exhibit changes in insulin sensitivity linking it to the pathophysiology of type 2 diabetes. ARL15 also interacts with PPARγ a protein highly involved in fat tissue development and implicated in obesity. These interactions indicate potential pathways through which ARL15 influences metabolic conditions making it a target of interest for disease research.
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일반 정보

서열 유사성

Belongs to the small GTPase superfamily. Arf family.

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제품 프로토콜

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타겟 정보

See full target information ARL15
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e23211 PubMed37773757

2023

Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Bai,Liz Bentley,Chao Ma,Navaratnam Naveenan,James Cleak,Yixing Wu,Michelle M Simon,Henrik Westerberg,Ramón Casero Cañas,Neil Horner,Rajesh Pandey,Keanu Paphiti,Ulrike Schulze,Joffrey Mianné,Tertius Hough,Lydia Teboul,Jeroen H F de Baaij,Roger D Cox
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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