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AB174457

Recombinant Human ARMS2 protein (denatured) (His tag N-Terminus)

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Recombinant Human ARMS2 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 107 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

Age-related maculopathy susceptibility protein 2, ARMS2

1 이미지
SDS-PAGE - Recombinant Human ARMS2 protein (denatured) (His tag N-Terminus) (AB174457)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ARMS2 protein (denatured) (His tag N-Terminus) (AB174457)

15% SDS-PAGE analysis of ab174457 (3 μg)

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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보완 제품

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLRLYPGPMVTEAEGKGGPEMASLSSSVVPVSFISTLRESVLDPGVGGEGASDKQRSKLSLSHSMIPAAKIHTELCLPAFFSPAGTQRRFQQPQHHLTLSIIHTAAR","proteinLength":"Full Length","predictedMolecularWeight":"13.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":107,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P0C7Q2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The ARMS2 protein also known as age-related maculopathy susceptibility 2 is a small protein with a molecular mass of around 12 kDa. Scientists find ARMS2 expressed particularly in the retina specifically in the photoreceptor layer. Its cellular presence suggests its involvement in retinal health and function though its precise cellular mechanisms are yet to be comprehensively understood indicating an area for further research.
Biological function summary

ARMS2 interacts with other cellular components to support retinal structure and function. Although ARMS2 is not confirmed as part of a larger protein complex it is suspected to play a role in the maintenance of extracellular matrix stability in the retina. This stability may help protect against changes in retinal cell organization and health relevant to visual processes.

Pathways

ARMS2 is implicated in pathways connected to cellular homeostasis and extracellular matrix regulation in the retina. While the precise pathways involving ARMS2 remain under investigation a noted association exists with complement system pathways. It has relationships with proteins like CFH which is central to complement regulation and inflammation control.

ARMS2 is notably linked to age-related macular degeneration (AMD) a leading cause of vision loss. The association with AMD suggests interactions with proteins affecting retinal integrity such as CFH emphasizing the role of inflammation and extracellular matrix maintenance in the disease's onset and progression. Understanding ARMS2 and its interactions could provide insights into potential therapeutic targets for AMD.
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일반 정보

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제품 프로토콜

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타겟 정보

See full target information ARMS2
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Product promise

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