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AB276271

Recombinant Human Biglycan protein (His tag)

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Recombinant Human Biglycan protein (His tag) is a Human Full Length protein, in the 38 to 368 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

SLRR1A, BGN, Biglycan, Bone/cartilage proteoglycan I, PG-S1

1 이미지
SDS-PAGE - Recombinant Human Biglycan protein (His tag) (AB276271)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Biglycan protein (His tag) (AB276271)

SDS-PAGE analysis of ab276271

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Primary Antibodies

AB109369

Anti-Biglycan antibody [EPR2959]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Biglycan antibody [EPR2959] (AB109369)

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Primary Antibodies

AB277636

Anti-Decorin antibody [EPR24097-105]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Decorin antibody [EPR24097-105] (AB277636)

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Assay Kits

AB256650

Human Biglycan Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human Biglycan Antibody Pair - BSA and Azide free (AB256650)

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Proteins & Peptides

AB322102

Recombinant Human Versican Protein Standard (His tag)

Sandwich ELISA - Recombinant Human Versican Protein Standard (His tag) (AB322102)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"DEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQVVYLHSNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYKK","proteinLength":"Full Length","predictedMolecularWeight":"38.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":368,"aminoAcidStart":38,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P21810","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Biglycan also known as BGN is a small leucine-rich proteoglycan with a molecular weight of roughly 38 kDa. Researchers frequently observe Biglycan in tissues such as bone cartilage and vasculature. The protein interacts with several other molecules in the extracellular matrix (ECM) including collagen and elastin to maintain the structural integrity of tissues. Through these interactions Biglycan plays an important role in supporting cell attachment and matrix organization.
Biological function summary

The protein Biglycan influences cellular processes such as growth and differentiation. It is part of a complex network within the ECM that modulates cell signaling. Biglycan interacts with growth factors like transforming growth factor-beta (TGF-beta) and binds to Toll-like receptors (TLRs) affecting immune responses. These capabilities reveal Biglycan’s involvement in tissue development and repair.

Pathways

Extracellular matrix modulation shows a significant role for Biglycan. It is involved in the TGF-beta signaling pathway and the inflammatory pathway mediated by TLRs. Through these pathways Biglycan interacts with proteins such as decorin and fibromodulin contributing to the regulation of collagen fibrillogenesis and inflammatory responses. Its role in these pathways highlights Biglycan’s influence in cellular communication and matrix regulation.

Biglycan has associations with osteoarthritis and muscular dystrophy. In osteoarthritis researchers observe altered expression levels of Biglycan which affects cartilage integrity. In muscular dystrophy the protein’s connection to dystrophin an important structural protein is noted. These associations illustrate Biglycan's impact on disease progression and its potential as a therapeutic target.
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일반 정보

기능

May be involved in collagen fiber assembly.

서열 유사성

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.

Post-translational modifications

The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.

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제품 프로토콜

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타겟 정보

May be involved in collagen fiber assembly.
See full target information BGN
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Product promise

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