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AB202216

Recombinant Human BNIP1 protein (denatured) (His tag N-Terminus)

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Recombinant Human BNIP1 protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

대체 명칭 보기

NIP1, SEC20L, TRG8, BNIP1, Vesicle transport protein SEC20, BCL2/adenovirus E1B 19 kDa protein-interacting protein 1, Transformation-related gene 8 protein, TRG-8

1 이미지
SDS-PAGE - Recombinant Human BNIP1 protein (denatured) (His tag N-Terminus) (AB202216)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human BNIP1 protein (denatured) (His tag N-Terminus) (AB202216)

3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.

주요 정보

Purity

>95% SDS-PAGE

ab202216 was purified using conventional chromatography.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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보완 제품

Primary Antibodies

AB151551

Anti-BNIP1 antibody [EPR10024]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BNIP1 antibody [EPR10024] (AB151551)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLSNQASWRKANLTCKIAIDNLEKAELLQGGDLLRQRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRREL","proteinLength":"Fragment","predictedMolecularWeight":"25.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":199,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q12981","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed : 15272311). Also plays a role in apoptosis (PubMed : 15272311, PubMed : 23896122, PubMed : 7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed : 23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).

서열 유사성

Belongs to the SEC20 family.

Post-translational modifications

Polyubiquitinated (PubMed:21931693, PubMed:23896122). 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1 (PubMed:21931693). Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion (PubMed:23896122).

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제품 프로토콜

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타겟 정보

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed : 15272311). Also plays a role in apoptosis (PubMed : 15272311, PubMed : 23896122, PubMed : 7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed : 23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
See full target information BNIP1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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