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AB235881

Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus)

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Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus) is a Human Fragment protein, in the 33 to 293 aa range, expressed in Baculovirus infected insect cells, with >95%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

CD157, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, Bone marrow stromal cell antigen 1, Cyclic ADP-ribose hydrolase 2, BST-1, cADPR hydrolase 2, BST1

1 이미지
SDS-PAGE - Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus) (AB235881)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Bone marrow stromal cell antigen 1 protein (His tag N-Terminus) (AB235881)

15% SDS-PAGE analysis of 3 μg ab235881.

28-40 kDa (Under reducing conditions)

주요 정보

Purity

>95% SDS-PAGE

Affinity purified

Endotoxin 레벨

< 0.1 EU/µg

발현 시스템

Baculovirus infected insect cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Assay Kits

AB267623

Human CD157 ELISA kit

Sandwich ELISA - Human CD157 ELISA kit (AB267623)

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Primary Antibodies

AB92395

Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5]

Flow Cytometry - Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5] (AB92395)

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Proteins & Peptides

AB60848

Recombinant human PKC zeta protein (GST tag N-Terminus)

Functional Studies - Recombinant human PKC zeta protein (AB60848)

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Primary Antibodies

AB137869

Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (AB137869)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"RWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"30.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":293,"aminoAcidStart":33,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q10588","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Bone marrow stromal cell antigen 1 (BST-1) also known as CD157 is a glycosylphosphatidylinositol-anchored protein with a molecular weight of approximately 38-42 kDa. You find BST-1 expression on the surface of various cell types especially within bone marrow stromal cells and cells of the immune system such as monocytes and macrophages. This protein functions as an ecto-enzyme with ADP-ribosyl cyclase activity and is part of the NADase enzyme family. Its mechanical role involves metabolizing extracellular NAD+ influencing cellular calcium signaling and energy metabolism.
Biological function summary

BST-1 contributes to the regulation of cellular interactions and immune responses. It participates in the organization of leukocyte trafficking and the formation of signal transduction cascades. BST-1 operates as a single protein but interacts with other membrane proteins to coordinate cellular communication. You can observe its function in processes like cell adhesion and migration impacting the immune surveillance and response systems.

Pathways

BST-1 plays a role in immune signaling and calcium-signaling pathways. In the immune system pathway it associates with molecules such as integrins to modulate leukocyte adhesion and transmigration. The calcium-signaling pathway is another key area where BST-1 interacts with intracellular proteins influencing various cellular targets and affecting metabolic processes critical for cell survival and proliferation.

Scientists have linked BST-1 to various conditions such as leukemia and chronic inflammation. Its expression levels often change in these diseases emphasizing its potential role in their progression. Researchers also explore the connection between BST-1 and other proteins like CD38 in the context of leukemia where both proteins might participate in cancer cell proliferation and survival. Understanding BST-1 in disease contexts provides insights into disease mechanisms and potential therapeutic strategies.
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일반 정보

기능

Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed : 7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).

서열 유사성

Belongs to the ADP-ribosyl cyclase family.

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제품 프로토콜

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타겟 정보

Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed : 7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).
See full target information BST1
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Product promise

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