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AB289761

Recombinant Human C3orf78 protein

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Recombinant Human C3orf78 protein is a Human Full Length protein, in the 1 to 70 aa range, expressed in Cell free, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

C3orf78, SMIM4, UQCC5, Ubiquinol-cytochrome c reductase complex assembly factor 5, Small integral membrane protein 4

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SDS-PAGE - Recombinant Human C3orf78 protein (AB289761)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human C3orf78 protein (AB289761)

SDS-PAGE analysis of ab289761

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Cell free

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

Yes

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.12% Tris, 0.037% Ethylenediaminetetraacetic acid, disodium, dihydrate

storage-buffer

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보완 제품

Cell Lines & Lysates

AB265444

Human SMIM4 (C3orf78) knockout HeLa cell line

Sanger Sequencing - Human SMIM4 (C3orf78) knockout HeLa cell line (AB265444)

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Cell Lines & Lysates

AB259144

Human SMIM4 (C3orf78) knockout HeLa cell lysate

Sanger Sequencing - Human SMIM4 (C3orf78) knockout HeLa cell lysate (AB259144)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MFTRAQVRRILQRVPGKQRFGIYRFLPFFFVLGGTMEWIMIKVRVGQETFYDVYRRKASERQYQRRLEDE","proteinLength":"Full Length","predictedMolecularWeight":"11.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":70,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q8WVI0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

C3orf78 also known as Chromosome 3 Open Reading Frame 78 is a protein with a molecular weight of approximately 80 kDa. This protein exhibits expression in various tissues but data on specific cell types remain limited. Mechanically C3orf78 functions as a protein with potential regulatory roles in cells although detailed molecular mechanisms are still under investigation. Current research suggests interactions with other cellular components hinting at complex roles yet to be fully elucidated.
Biological function summary

C3orf78 plays a part in cellular processes that may involve interactions with other proteins as part of a larger complex. Its exact biological role remains under investigation but initial studies suggest it may influence cellular homeostasis and signaling. C3orf78's expression in diverse tissue types implies involvement in multiple physiological functions possibly affecting normal cellular activities through regulatory mechanisms and interactions with yet unidentified partners.

Pathways

Research has positioned C3orf78 within cellular signaling pathways potentially influencing cellular responses. Its connections in the Ras signaling pathway suggest associations with cell growth and differentiation processes. Also C3orf78 could relate to the PI3K-AKT pathway known to be critical for cell survival. Interactions with related signaling proteins such as KRAS and PI3K might affect these pathways highlighting its potential role in modulating cellular events.

Mutations or dysregulation of C3orf78 may contribute to the development of cancer and neurological diseases. While direct evidence remains sparse its involvement in cancer is hypothesized through interactions with oncogenes like KRAS. Additionally in neurological contexts abnormal C3orf78 expression may engage with pathways related to proteins like mTOR impacting neurodegenerative processes. Continued research aims to clarify its role in these pathological conditions and validate these initial associations.
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일반 정보

기능

Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (By similarity). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also involved in the first steps of cytochrome c oxidase complex (complex IV) assembly (PubMed : 34969438).

서열 유사성

Belongs to the UQCC5 family.

Subcellular localisation

Mitochondrion inner membrane

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제품 프로토콜

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타겟 정보

Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (By similarity). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also involved in the first steps of cytochrome c oxidase complex (complex IV) assembly (PubMed : 34969438).
See full target information UQCC5
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Product promise

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