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AB164557

Recombinant Human CAPNS2 protein (GST tag N-Terminus)

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Recombinant Human CAPNS2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 248 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

Calpain small subunit 2, CSS2, Calcium-dependent protease small subunit 2, CAPNS2

1 이미지
SDS-PAGE - Recombinant Human CAPNS2 protein (GST tag N-Terminus) (AB164557)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CAPNS2 protein (GST tag N-Terminus) (AB164557)

ab164557 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Proteins & Peptides

AB231157

Recombinant Human Calpain 2 protein (His tag)

SDS-PAGE - Recombinant Human Calpain 2 protein (His tag) (AB231157)

  • 1
  • 1
Assay Kits

AB65308

Calpain Activity Assay Kit

Functional Studies - Calpain Activity Assay Kit (AB65308)

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  • 1
Proteins & Peptides

AB152676

Recombinant Human beta Sarcoglycan protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human beta Sarcoglycan protein (GST tag N-Terminus) (AB152676)

  • 0
  • 0
Proteins & Peptides

AB114576

Recombinant Human Calpain 3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Calpain 3 protein (GST tag N-Terminus) (AB114576)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product was previously labelled as Calpain S2.
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서열 정보

[{"linker":null,"sequence":"MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":248,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96L46","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CAPNS2 also known as Calpain Small Subunit 2 or CSS2 is a protein that is part of the calpain family a group of calcium-dependent non-lysosomal cysteine proteases. It has a molecular mass of approximately 29 kDa. CAPNS2 plays a role in intracellular signaling processes by mediating the cleavage of various substrates. It is expressed in numerous tissues with higher levels observed in skeletal muscle and brain reflecting its diverse physiological roles.
Biological function summary

CAPNS2 contributes to the regulation and modulation of cytoskeletal remodeling and cell motility. As a component of the calpain holoenzyme complex it partners with the large catalytic subunits CAPN1 and CAPN2 facilitating the calpain's proteolytic activity. This relationship highlights CAPNS2's role in enabling precise and controlled cellular processes such as cell cycle progression and signal transduction.

Pathways

CAPNS2 integrates into the calcium signaling pathway and is involved in the regulation of the cytoskeleton. In the calcium signaling pathway it interacts with CAPN2 participating in the activation of downstream effectors that convey calcium's pivotal roles in cellular functions. Additionally through its engagement in cytoskeletal reorganization CAPNS2 influences cell shape and migration playing a part alongside proteins like filamin and talin.

CAPNS2's malfunction or deregulation associates with neurodegenerative diseases and muscular dystrophies. In neurodegenerative conditions such as Alzheimer's CAPNS2 interacts with tau protein where dysregulation may contribute to neuronal cell death. Its role in muscular dystrophies links to the impaired function of related proteins like dystrophin underlining the importance of CAPNS2 in maintaining muscle integrity and function.
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일반 정보

기능

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.

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제품 프로토콜

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타겟 정보

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.
See full target information CAPNS2
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Product promise

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