Recombinant Human Caveolin-2 protein (GST tag N-Terminus)
Be the first to review this product! 리뷰 제출
|
(0 출판물)
Recombinant Human Caveolin-2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 162 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
대체 명칭 보기
Caveolin-2, CAV2
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Caveolin-2 protein (GST tag N-Terminus) (AB114515)
ab114515 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.
보완 제품
![Immunocytochemistry/ Immunofluorescence - Anti-Caveolin-2 antibody [EPR5471] (AB133484)](https://content.abcam.com/products/images/caveolin-2-antibody-epr5471-ab133484--immunocytochemistry-immunofluorescence-img114275.jpg)
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
Purification 테크닉
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Caveolin-2 participates in modulating cellular functions such as signal transduction cholesterol homeostasis and endocytosis. As part of the caveolae complex it cooperates with caveolin-1 to regulate lipid raft domains influencing the movement and function of molecules within the cell. The presence of caveolin-2 helps maintain the caveolae structure and is involved in cellular responses to mechanical stress.
Pathways
Caveolin-2 is implicated in the regulation of insulin signaling and the Ras-MAPK signaling pathway. In the insulin signaling pathway it forms complexes with caveolin-1 and other proteins like IRS-1 affecting glucose uptake in cells. In the Ras-MAPK pathway caveolin-2 interacts with signaling molecules associated with the pathway modulating cell proliferation and survival.
일반 정보
기능
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
서열 유사성
Belongs to the caveolin family.
Post-translational modifications
Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).
타겟 정보
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com