Recombinant Human CCK4 protein (His tag) is a Human Fragment protein, in the 31 to 704 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE, Mass Spec.
대체 명칭 보기
CCK4, PTK7, Inactive tyrosine-protein kinase 7, Colon carcinoma kinase 4, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, CCK-4
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human CCK4 protein (His tag) (AB241239)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab241239 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) CCK4.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human CCK4 protein (His tag) (AB241239)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of ab241239 could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) CCK4.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CCK4 protein (His tag) (AB241239)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab241239.
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CCK4 participates in cellular signaling involved in adhesion and cell migration. It localizes predominantly in the membranes participating in complex cellular environments such as the Wnt signaling complex. This suggests a role in maintaining cellular architecture and signaling pathways that influence developmental processes. Its interactions within these complexes can help maintain balance and functional integrity in developing tissues.
Pathways
CCK4 engages in vital pathways influencing cell adhesion and movement including the planar cell polarity (PCP) pathway and Wnt signaling pathway. Within these pathways CCK4 interacts with proteins such as Dishevelled and Frizzled establishing its role in guiding cellular and developmental patterns. These interactions regulate important aspects of cell polarity and directional movement during embryonic development.
일반 정보
기능
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
서열 유사성
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Post-translational modifications
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
타겟 정보
Product promise
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