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AB289764

Recombinant Human CCR8 protein

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Recombinant Human CCR8 protein is a Human Full Length protein, in the 1 to 355 aa range, expressed in Cell free, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

CDw198, CKRL1, CMKBR8, CMKBRL2, CCR8, C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, Chemokine receptor-like 1, GPR-CY6, TER1, CKR-L1, GPRCY6

1 이미지
SDS-PAGE - Recombinant Human CCR8 protein (AB289764)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CCR8 protein (AB289764)

SDS-PAGE analysis of ab289764

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Cell free

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

Yes

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.79% Sodium chloride, 0.14% Disodium hydrogenorthophosphate, 0.05% 2-Octadecoxyethanol, 0.024% Potassium phosphate monobasic, 0.02% Potassium chloride

storage-buffer

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보완 제품

Proteins & Peptides

AB289735

Recombinant Human CCR4 protein

SDS-PAGE - Recombinant Human CCR4 protein (AB289735)

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Proteins & Peptides

AB131829

Recombinant Human GPR2/CCR10 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GPR2/CCR10 protein (GST tag N-Terminus) (AB131829)

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Primary Antibodies

AB227036

Anti-CCR6 antibody [EPR22259]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCR6 antibody [EPR22259] (AB227036)

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Primary Antibodies

AB8019

Anti-CCR8 antibody

Western blot - Anti-CCR8 antibody (AB8019)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL","proteinLength":"Full Length","predictedMolecularWeight":"41.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":355,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"P51685","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The CC chemokine receptor 8 abbreviated as CCR8 is a G protein-coupled receptor with an approximate molecular mass of 41 kDa. It is also known as CDw198. Expression of CCR8 protein is observed mainly in T cells particularly CD4+ T cells and natural killer cells. Antibody against CCR8 like anti-CCR8 can be used to study the expression of this receptor in tissues via immunohistochemistry (IHC) which may be referred to as CCR8 IHC.
Biological function summary

CCR8 plays a role in immune cell signaling and migration. This receptor interacts with its ligand CCL1 to mediate chemotaxis guiding cells to sites of inflammation or injury. CCR8 forms a part of the immune response machinery facilitating communication between cells. Through these interactions it influences the function of various immune cells such as regulatory T cells and supports the maintenance of immune homeostasis.

Pathways

CCR8 is involved in chemokine signaling pathways that regulate immune responses. It operates within the broader context of the chemokine receptor family including receptors like CCR4. These pathways are important for directing lymphocyte migration and are implicated in inflammation and immune surveillance processes. The engagement of CCR8 modulates downstream signaling events that influence T cell differentiation and immune cell recruitment.

Alterations in CCR8 expression or function relate to inflammatory diseases and certain cancers. Aberrant expression of CCR8 associates with disorders such as autoimmune diseases and Hodgkin's lymphoma. In cancer the cross-talk between CCR8 and its ligands can promote a protumorigenic environment aiding tumor progression. Connections exist between CCR8 and other receptors like CCR4 in these pathologies highlighting its role in disease development and potential as a therapeutic target.
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일반 정보

기능

G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed : 23999500, PubMed : 35041514). Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells (PubMed : 23999500). In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (PubMed : 35041514). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity).. (Microbial infection) Acts as a coreceptor for HIV-1 and HIV-2 viruses.. (Microbial infection) Acts as a receptor for Kaposi virus protein vCCL1/K6 and thereby inhibits apoptosis in the targeted cells.

서열 유사성

Belongs to the G-protein coupled receptor 1 family.

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제품 프로토콜

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타겟 정보

G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed : 23999500, PubMed : 35041514). Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells (PubMed : 23999500). In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (PubMed : 35041514). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity).. (Microbial infection) Acts as a coreceptor for HIV-1 and HIV-2 viruses.. (Microbial infection) Acts as a receptor for Kaposi virus protein vCCL1/K6 and thereby inhibits apoptosis in the targeted cells.
See full target information CCR8
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Product promise

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