JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235677

Recombinant Human CDR2 protein (His tag)

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human CDR2 protein (His tag) is a Human Full Length protein, in the 1 to 454 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

PCD17, CDR2, Cerebellar degeneration-related protein 2, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen

3 이미지
Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235677 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.

Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human CDR2 protein (His tag) (AB235677)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235677 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CDR2.

SDS-PAGE - Recombinant Human CDR2 protein (His tag) (AB235677)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CDR2 protein (His tag) (AB235677)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab235677.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Escherichia coli

Tags

6x His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

서열 정보

[{"linker":null,"sequence":"MLAENLVEEFEMKEDEPWYDHQDLQQDLQLAAELGKTLLDRNTELEDSVQQMYTTNQEQLQEIEYLTKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLVADSKASQQKILSLTETIECLQTNIDHLQSQVEELKSSGQGRRSPGKCDQEKPAPSFACLKELYDLRQHFVYDHVFAEKITSLQGQPSPDEEENEHLKKTVTMLQAQLSLERQKRVTMEEEYGLVLKENSELEQQLGATGAYRARALELEAEVAEMRQMLQSEHPFVNGVEKLVPDSLYVPFKEPSQSLLEEMFLTVPESHRKPLKRSSSETILSSLAGSDIVKGHEETCIRRAKAVKQRGISLLHEVDTQYSALKVKYEELLKKCQEEQDSLSHKAVQTSRAAAKDLTGVNAQSEPVASGWELASVNPEPVSSPTTPPEYKALFKEIFSCIKKTKQEIDEQRTKYRSLSSHS","proteinLength":"Full Length","predictedMolecularWeight":"55.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":454,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q01850","tags":[{"tag":"6x His","terminus":"N-Terminus"}]}]

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CDR2 also known as Cerebellar Degeneration-Related Protein 2 weighs approximately 52 kDa. It is primarily located in neuronal tissues particularly in the cerebellum. The protein is part of a family of proteins that share similarities including CDR2L which is also found in neuronal tissues. CDR2 plays a mechanical role in regulating neuron function and growth. While it has less common names this protein is consistently referred to in studies involving paraneoplastic neurological disorders.
Biological function summary

CDR2 regulates neuronal signaling and motor control. It interacts with proteins involved in cell cycle control and may form part of a protein complex affecting protein synthesis. Recent research suggests that CDR2 operates in regulating neuronal activity and response to cellular stress. The protein’s expression patterns indicate its significance in maintaining proper cerebellar function and coordination.

Pathways

CDR2 aligns with signaling pathways linked to cerebellar function and neurodegeneration. It is implicated in the mTOR signaling pathway which is important for cell growth and survival alongside proteins like mTOR and RICTOR. The protein is also associated with the beta-catenin signaling pathway suggesting its involvement in processes like cytoskeletal organization and neural cell adhesion.

CDR2 is connected to paraneoplastic cerebellar degeneration and certain types of cancers such as ovarian and breast cancer. These diseases link to the immune response against tumors that mistakenly target neuronal tissue. The protein Yo antibodies are associated with this condition showing a strong connection to CDR2. Their presence in patients indicates an autoimmune aspect where the target’s involvement leads to cerebellar damage and subsequent motor dysfunction.

일반 정보

서열 유사성

Belongs to the CDR2 family.

제품 프로토콜

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com