JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB114408

Recombinant Human CETP protein (GST tag N-Terminus)

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human CETP protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 493 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

대체 명칭 보기

Cholesteryl ester transfer protein, Lipid transfer protein I, CETP

1 이미지
SDS-PAGE - Recombinant Human CETP protein (GST tag N-Terminus) (AB114408)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CETP protein (GST tag N-Terminus) (AB114408)

12.5% SDS-PAGE analysis of ab114408 stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

style
left-column

보완 제품

Reagents, Controls & Accessories

AB325996

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands) (AB325996)

  • 0
  • 0
Primary Antibodies

AB157183

Anti-CETP antibody [EPR13]

RabMAb|Recombinant

Immunoprecipitation - Anti-CETP antibody [EPR13] (AB157183)

  • 0
  • 0
Proteins & Peptides

AB174391

Recombinant Human Apolipoprotein A V/APOA5 - BSA and Azide free (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Apolipoprotein A V/APOA5 - BSA and Azide free (denatured) (His tag N-Terminus) (AB174391)

  • 0
  • 0
Proteins & Peptides

AB53376

Recombinant Human PON1 protein

Western blot - Recombinant Human PON1 protein (AB53376)

  • 0
  • 0
Proteins & Peptides

AB158937

Recombinant Human Myosin light chain 3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Myosin light chain 3 protein (GST tag N-Terminus) (AB158937)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(for recombinant protein)</p>" } } }
style
left-column
style
left-column

서열 정보

[{"linker":null,"sequence":"MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESIQSFLQSMITAVGIPEVTSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS","proteinLength":"Full Length","predictedMolecularWeight":"79.97 kDa","actualMolecularWeight":null,"aminoAcidEnd":493,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P11597","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CETP also known as Cholesteryl Ester Transfer Protein is a plasma glycoprotein with a molecular mass of approximately 74 kDa. It is primarily expressed in the liver and circulates in the bloodstream. CETP mediates the transfer of cholesteryl esters and triglycerides between high-density lipoproteins (HDL) and low-density lipoproteins (LDL) influencing lipid balance in human plasma. This protein is essential for regulating the distribution and composition of HDL and LDL particles impacting lipid homeostasis.
Biological function summary

CETP plays a role in lipid metabolism by facilitating the redistribution of lipids among various lipoprotein particles. CETP does not function as part of a larger molecular complex but actively interacts with lipoproteins in a reversible manner. Its activity affects the levels of HDL cholesterol often referred to as "good cholesterol" and contributes to maintaining lipid levels within physiological limits. By modulating the lipid exchanges CETP influences atherosclerosis progression and cardiovascular health.

Pathways

CETP interacts significantly with lipoprotein metabolism and reverse cholesterol transport pathways. It works alongside key proteins such as apolipoprotein A-I and apolipoprotein B which are present in HDL and LDL particles respectively. CETP activity in these pathways modulates the cholesterol efflux capability of HDL affecting lipid clearance from tissues back to the liver. These interactions ensure the maintenance of cholesterol equilibrium and are vital in lipid recycling processes.

CETP is closely linked to cardiovascular diseases and atherosclerosis. Elevated CETP activity correlates with low HDL cholesterol levels and higher risk of coronary artery disease. CETP inhibitors have been researched for their potential to increase HDL levels and reduce cardiovascular risk. Furthermore CETP activity influences the pathology of metabolic syndrome where lipid imbalances exacerbate the condition. Proteins related to CETP in these contexts include HDL and LDL which are altered in their distributions by CETP's activity impacting disease progression and management.
style
left-column

일반 정보

기능

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed : 24293641, PubMed : 3281933, PubMed : 3600759). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed : 17237796).

서열 유사성

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

style
left-column

제품 프로토콜

style
left-column

타겟 정보

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed : 24293641, PubMed : 3281933, PubMed : 3600759). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed : 17237796).
See full target information CETP
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com