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AB276395

Recombinant Human CLEC4D protein (His tag)

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Recombinant Human CLEC4D protein (His tag) is a Human Fragment protein, in the 52 to 215 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

CD368, CLECSF8, MCL, CLEC4D, C-type lectin domain family 4 member D, C-type lectin superfamily member 8, C-type lectin-like receptor 6, Dendritic cell-associated C-type lectin 3, CLEC-6, DC-associated C-type lectin 3, Dectin-3

1 이미지
SDS-PAGE - Recombinant Human CLEC4D protein (His tag) (AB276395)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CLEC4D protein (His tag) (AB276395)

SDS-PAGE analysis of ab276395

주요 정보

Purity

>92% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Primary Antibodies

AB175021

Anti-CLEC4D antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4D antibody (AB175021)

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Primary Antibodies

AB281584

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001]

20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunocytochemistry/ Immunofluorescence - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] (AB281584)

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  • 4
Primary Antibodies

AB5103

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

  • 4
  • 28
Primary Antibodies

AB310335

Anti-Neutrophil Elastase antibody [EPR28386-66]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Multiplex immunohistochemistry - Anti-Neutrophil Elastase antibody [EPR28386-66] (AB310335)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"GTGVHKLEHHAKLKCIKEKSELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKTWAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSYFLGLRDENAKGQWRWVDQTPFNPRRVFWHKNEPDNSQGENCVVLVYNQDKWAWNDVPCNFEASRICKIPGTTLN","proteinLength":"Fragment","predictedMolecularWeight":"21.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":215,"aminoAcidStart":52,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8WXI8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system : recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed : 23602766, PubMed : 23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed : 23602766, PubMed : 23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed : 23602766, PubMed : 23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed : 23911656). Functions as an endocytic receptor (PubMed : 14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed : 14971047).

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제품 프로토콜

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타겟 정보

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system : recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed : 23602766, PubMed : 23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed : 23602766, PubMed : 23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed : 23602766, PubMed : 23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed : 23911656). Functions as an endocytic receptor (PubMed : 14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed : 14971047).
See full target information CLEC4D
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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