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AB165315

Recombinant Human CMPK2 protein (GST tag N-Terminus)

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Recombinant Human CMPK2 protein (GST tag N-Terminus) is a Human Fragment protein, in the 151 to 250 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

Nucleoside-diphosphate kinase, CMPK2

1 이미지
SDS-PAGE - Recombinant Human CMPK2 protein (GST tag N-Terminus) (AB165315)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CMPK2 protein (GST tag N-Terminus) (AB165315)

ab165315 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Primary Antibodies

AB194567

Anti-CMPK2 antibody

Western blot - Anti-CMPK2 antibody (AB194567)

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Primary Antibodies

AB302504

Anti-BCKDHA (phospho S292) antibody [EPR27489-76]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BCKDHA (phospho S292) antibody [EPR27489-76] (AB302504)

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Assay Kits

AB309441

Human Protective protein/Cathepsin A (PPCA) ELISA Kit

Recombinant

Sandwich ELISA - Human Protective protein/Cathepsin A (PPCA) ELISA Kit (AB309441)

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Primary Antibodies

AB181129

Anti-Protective protein/Cathepsin A (PPCA) antibody [EPR10434]

RabMAb|Recombinant

Immunoprecipitation - Anti-Protective protein/Cathepsin A (PPCA) antibody [EPR10434] (AB181129)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"GACQEAPRPHLGEFEADPRGQLWQRLWEVQDGRRLQVGCAQVVPVPEPPLHPVVPDLPSSVVFPDREAARAVLEECTSFIPEARAVLDLVDQCPKQIQKG","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":250,"aminoAcidStart":151,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q5EBM0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways (PubMed : 17999954, PubMed : 30083606, PubMed : 36930652, PubMed : 37075076). Restricts the replication of multiple viruses including flaviviruses or coronaviruses (PubMed : 30083606, PubMed : 36930652, PubMed : 37075076). Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (PubMed : 36930652). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (PubMed : 37075076). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (By similarity). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (By similarity). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (By similarity).

서열 유사성

Belongs to the thymidylate kinase family.

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제품 프로토콜

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타겟 정보

Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways (PubMed : 17999954, PubMed : 30083606, PubMed : 36930652, PubMed : 37075076). Restricts the replication of multiple viruses including flaviviruses or coronaviruses (PubMed : 30083606, PubMed : 36930652, PubMed : 37075076). Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (PubMed : 36930652). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (PubMed : 37075076). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (By similarity). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (By similarity). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (By similarity).
See full target information UMP-CMP kinase 2, mitochondrial
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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