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AB276620

Recombinant Human CPLX3 protein (His tag)

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Recombinant Human CPLX3 protein (His tag) is a Human Fragment protein, in the 1 to 154 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

Nbla11589, CPLX3, Complexin-3, Complexin III, CPX III

1 이미지
SDS-PAGE - Recombinant Human CPLX3 protein (His tag) (AB276620)
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Supplier Data

SDS-PAGE - Recombinant Human CPLX3 protein (His tag) (AB276620)

SDS-PAGE analysis of ab276620

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Primary Antibodies

AB308463

Anti-CPLX3 antibody [EPR28433-43]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPLX3 antibody [EPR28433-43] (AB308463)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELPRELAKMIEEDTEEEEEKASVLGQLASLPGLNLGSLKDKAQATLGDLKQSAEK","proteinLength":"Fragment","predictedMolecularWeight":"19.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":154,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8WVH0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CPLX3 also known as Complexin-3 is a small synaptic protein with a molecular weight of approximately 18 kDa. It is expressed abundantly in the brain specifically in sensory-related areas where it acts at the presynaptic terminal. CPLX3 belongs to the complexin family which includes Complexin-1 Complexin-2 and Complexin-4. Its expression patterns suggest a role in the central nervous system (CNS) in neurons associated with sensory processing.
Biological function summary

Complexin-3 participates in synaptic vesicle exocytosis by binding to the SNARE complex. This interaction helps regulate the release of neurotransmitters which is essential for proper synaptic function. CPLX3 plays a part in the synaptic vesicle cycle and ensures the precise timing of neurotransmitter release. It may also modulate synaptic plasticity which influences learning and memory processes in the CNS.

Pathways

Complexin-3 operates within the synaptic vesicle cycle and neurotransmitter release pathways. It collaborates closely with SNARE proteins like Syntaxin and Synaptobrevin both key for membrane fusion and neurotransmitter release. CPLX3 fine-tunes these processes impacting the efficiency and dynamics of synaptic transmission. Its function in these pathways highlights its relevance in regulating synaptic communication and plasticity.

Complexin-3 has been implicated in neurological conditions such as schizophrenia and autism spectrum disorders. Altered expression levels of CPLX3 may disrupt synaptic signaling contributing to the pathophysiology of these conditions. Its interaction with SNARE proteins underlies its potential involvement in these disorders. Understanding CPLX3's role in these diseases can inform therapeutic strategies for managing synaptic dysfunctions associated with neurological conditions.
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일반 정보

기능

Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity).

서열 유사성

Belongs to the complexin/synaphin family.

Post-translational modifications

Farnesylation mediates presynaptic targeting.

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제품 프로토콜

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타겟 정보

Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity).
See full target information CPLX3
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Product promise

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