Recombinant Human CRMP2 protein (GST tag N-Terminus)
Recombinant Human CRMP2 단백질 (GST tag N-Terminus)
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Recombinant Human CRMP2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 572 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
대체 명칭 보기
CRMP2, ULIP2, DPYSL2, Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, N2A3, Unc-33-like phosphoprotein 2, CRMP-2, ULIP-2
- WB
Lab
Western blot - Recombinant Human CRMP2 protein (GST tag N-Terminus) (AB114269)
Blocking and dilution buffer : 5% NFDM /TBST
All lanes:
Western blot - Anti-CRMP1 + CRMP2 antibody [EPR7792] (<a href='/ko/products/primary-antibodies/crmp1-crmp2-antibody-epr7792-ab129082'>ab129082</a>) at 1/1000 dilution
Lanes 1 and 3:
Western blot - Recombinant Human CRMP1 protein (His tag N-Terminus) (<a href='/ko/products/proteins-peptides/recombinant-human-crmp1-protein-ab202599'>ab202599</a>)
Lanes 2 and 4:
Western blot - Recombinant Human CRMP2 protein (GST tag N-Terminus) (ab114269)
Secondary
All lanes:
Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/ko/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution
false
Exposure time: 3s
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human CRMP2 protein (GST tag N-Terminus) (AB114269)
12.5% SDS-PAGE analysis of ab114269.
Stained with Coomassie Blue.
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
Purification 테크닉
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
일반 정보
기능
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
서열 유사성
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Post-translational modifications
3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
타겟 정보
Product promise
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