Recombinant Human DR6 protein (Fc tag C-Terminus + His tag C-Terminus)
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Recombinant Human DR6 protein (Fc tag C-Terminus + His tag C-Terminus) is a Human Fragment protein, in the 42 to 349 aa range, expressed in Baculovirus infected insect cells, with >85%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
대체 명칭 보기
CD358, DR6, UNQ437/PRO868, TNFRSF21, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human DR6 protein (Fc tag C-Terminus + His tag C-Terminus) (AB235878)
15% SDS-PAGE analysis of 3 μg ab235878.
50-70 kDa (Under reducing conditions)
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
Purification 테크닉
배송 시 보관 조건
적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
DR6 acts as a mediator in cell death signaling pathways. It associates with other proteins to form a death-inducing signaling complex triggering apoptotic pathways upon activation by specific ligands. DR6 is involved in regulating cell growth differentiation and survival. It also plays a role in modulating the immune response especially the adaptive immune response by influencing T-cell activation and proliferation.
Pathways
DR6 is involved in apoptosis and immune signaling pathways. It interacts with proteins such as caspases and adaptor proteins in the apoptotic pathways. In the immune system DR6 is related to proteins like TRAF family members which help in transmitting signals required for T-cell responses. DR6 influences several downstream effects that are critical for maintaining cellular homeostasis and immune regulation.
일반 정보
기능
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis : recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed : 34012073).
Post-translational modifications
Oxidized in response to reactive oxygen species (ROS), leading to endocytosis.
타겟 정보
Product promise
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