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AB123187

Recombinant Human ECHDC1 protein (His tag N-Terminus)

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Recombinant Human ECHDC1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 307 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

Ethylmalonyl-CoA decarboxylase, Enoyl-CoA hydratase domain-containing protein 1, Methylmalonyl-CoA decarboxylase, MMCD, ECHDC1

1 이미지
SDS-PAGE - Recombinant Human ECHDC1 protein (His tag N-Terminus) (AB123187)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ECHDC1 protein (His tag N-Terminus) (AB123187)

15% SDS-PAGE showing ab123187 (3μg).

주요 정보

Purity

>95% SDS-PAGE

ab123187 is purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Primary Antibodies

AB188222

Anti-GPNMB antibody [EPR18226-147]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GPNMB antibody [EPR18226-147] (AB188222)

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  • 1
Cell Lines & Lysates

AB266053

Human ECHDC1 knockout HeLa cell line

Sanger Sequencing - Human ECHDC1 knockout HeLa cell line (AB266053)

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  • 0
Cell Lines & Lysates

AB258855

Human ECHDC1 knockout HeLa cell lysate

Sanger Sequencing - Human ECHDC1 knockout HeLa cell lysate (AB258855)

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  • 0
Proteins & Peptides

AB151652

Recombinant Human GPNMB protein

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  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNERDLLGTVWGGPANLEAIAKKGKFNKGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNERDLLGTVWGGPANLEAIAKKGKFNK","proteinLength":"Full Length","predictedMolecularWeight":"35.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":307,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NTX5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ECHDC1 also known as 'enoyl-CoA hydratase domain-containing protein 1' plays a role in fatty acid metabolism through its enzymatic activity. It weighs around 39 kDa and can be found in various tissues but it has higher expression levels in the heart and muscle tissues. This protein participates in metabolic processes by catalyzing the hydration of enoyl-CoA during the beta-oxidation of fatty acids.
Biological function summary

EVT-888 (another name for ECHDC1 used in some studies) acts as a component that affects metabolic pathways by mediating reactions associated with energy production. Though it is not actively considered formally as a part of large enzyme complexes ECHDC1 indirectly relates to mitochondrial function and energy regulation. It influences long-chain fatty acid breakdown assisting cells to maintain energy homeostasis.

Pathways

ECHDC1 influences key metabolic pathways like the beta-oxidation pathway of fatty acids and the mitochondrial respiration chain. This protein interacts closely with other proteins such as ACADVL (very long-chain specific acyl-CoA dehydrogenase) and HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) playing a central role in energy conversion and mitochondrial efficiency.

Alterations in ECHDC1 expression or function may associate with metabolic syndromes and cardiomyopathies due to its involvement in fatty acid metabolism and energy production. Disrupted interactions with metabolic proteins like HADHA and ACADVL can result in energy production deficits linking ECHDC1 to inherited metabolic disorders related to mitochondrial anomalies.
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일반 정보

기능

Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed : 22016388). Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).

서열 유사성

Belongs to the enoyl-CoA hydratase/isomerase family.

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제품 프로토콜

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타겟 정보

Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed : 22016388). Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer (By similarity). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity).
See full target information ECHDC1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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