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AB235678

Recombinant Human ENOX2/tNOX protein (Tagged)

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Recombinant Human ENOX2/tNOX protein (Tagged) is a Human Full Length protein, in the 1 to 610 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

COVA1, ENOX2, Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX

1 이미지
SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (AB235678)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (AB235678)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel of ab235678.

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

10x His tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Primary Antibodies

AB210751

Anti-ENOX2/tNOX antibody

Immunocytochemistry/ Immunofluorescence - Anti-ENOX2/tNOX antibody (AB210751)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Previously labelled as ENOX2.
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서열 정보

[{"linker":null,"sequence":"MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT","proteinLength":"Full Length","predictedMolecularWeight":"77.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":610,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16206","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ENOX2 also known as tumor-associated NADH oxidase or tNOX is a protein involved in cellular processes including growth and apoptosis. It has a molecular mass of approximately 46 kDa and exhibits unique activity patterns cycling with a 24-minute period. ENOX2 is expressed mostly in cancer cells but not in normal cells which makes it a potential biomarker for various types of cancer. This expression pattern offers a significant advantage for targeted cancer therapies focusing efforts on treating malignant cells while sparing healthy tissues.
Biological function summary

This enzyme plays a role in electron transport and cell surface NADH oxidase activity. ENOX2 forms part of a complex involved in the regulation of cellular energy and growth directly impacting cellular proliferation rates. It contributes to the maintenance of extracellular environments that support cancer cell survival and proliferation. Its activity parallels growth rates in cancer cells further implicating its function in tumorigenesis and oncogenic processes.

Pathways

ENOX2 operates within the NADH/NAD+ redox system and impacts the pathways that govern cellular metabolism and energy flow. It interacts with proteins in the oxidative phosphorylation pathway which is critical for ATP production and cellular energy regulation. ENOX2 links to proteins such as cytochrome c oxidase and its influence extends to pathways associated with glycolytic processes and mitochondrial function illustrating its central part in metabolic reprogramming in cancer cells.

ENOX2 is strongly associated with cancer serving as both a diagnostic marker and a potential therapeutic target. Its cancer-specific expression pattern exposes its linkage to oncogenic pathways. ENOX2 is connected to other proteins implicated in cancer such as HER2/neu playing a role in breast cancer. Additionally it relates to neurodegenerative disorders where alterations in cellular metabolism contribute to disease progression although the precise mechanisms remain under investigation.
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일반 정보

기능

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.

서열 유사성

Belongs to the ENOX family.

Post-translational modifications

Glycosylated.

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제품 프로토콜

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타겟 정보

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
See full target information ENOX2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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