Recombinant human Eph receptor A3 protein (His tag)
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Recombinant human Eph receptor A3 protein (His tag) is a Human Fragment protein, in the 1 to 541 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
대체 명칭 보기
ETK, ETK1, HEK, TYRO4, EPHA3, Ephrin type-A receptor 3, EPH-like kinase 4, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, EK4, hEK4, Human embryo kinase, Eph-like tyrosine kinase 1
- FuncS
Supplier Data
Functional Studies - Recombinant human Eph receptor A3 protein (His tag) (AB276394)
Measured by its binding ability in a functional ELISA.
Immobilized human EPHA3-His at 10 μg/ml (100 μl/well) can bind human EphrinA5-Fc.
The EC50 of human EphrinA5-Fc is 6.2-14.6 ng/ml.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human Eph receptor A3 protein (His tag) (AB276394)
SDS-PAGE analysis of ab276394.
보완 제품
Proteins & Peptides
AB270576
Recombinant Human CD19 protein (Fc tag C-Terminus + His tag C-Terminus)
- 0
- 0
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
EphA3 influences cellular organization movement and positioning through its involvement in contact-dependent signaling. It acts as part of a larger receptor-ligand complex which mediates bidirectional signaling between cells. This interaction generally leads to changes in the cytoskeleton impacting cell shape and locomotion. EphA3’s signaling can regulate developmental processes such as axon guidance angiogenesis and tissue boundary formation.
Pathways
EphA3 modulates various important signaling pathways such as the PI3K/AKT pathway and the Rho family GTPase pathway. It interacts with proteins like Ephrin-A5 and other Eph receptors coordinating complex cellular signaling networks. These interactions contribute to the regulation of cell proliferation survival and migration influencing tissue patterning and organ development.
일반 정보
기능
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (PubMed : 11870224, PubMed : 12794130). Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (By similarity). Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration (PubMed : 11870224). Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed : 12794130). Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity).
서열 유사성
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Post-translational modifications
Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.
타겟 정보
Product promise
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