Recombinant Human Ephrin A1 protein (denatured) (His tag N-Terminus)
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Recombinant Human Ephrin A1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 19 to 182 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
대체 명칭 보기
EPLG1, LERK1, TNFAIP4, EFNA1, Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, LERK-1, TNF alpha-induced protein 4
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Ephrin A1 protein (denatured) (His tag N-Terminus) (AB113867)
3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.
보완 제품
Proteins & Peptides
AB227418
Recombinant human CD116 protein (Active) (His tag C-Terminus)
Bioactive
- 0
- 0
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
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적절한 단기 보관 기간
적절한 단기 보관 조건
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분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Ephrin A1 contributes to the regulation of cell movement and adhesion. It often forms part of a receptor-ligand complex with Eph receptors on adjacent cells. This interaction controls the guidance of axonal growth angiogenesis and tissue boundary formation. In the nervous system ephrin A1 influences the segregation of synaptic connections playing a role in developing the proper neural circuitry. Its expression patterns suggest its involvement in vascular processes and other critical physiological functions.
Pathways
Ephrin A1 is significantly involved in various signaling pathways that mediate cellular attachment and repulsion features. Notably it participates in the Eph/ephrin signaling and the Rho family GTPase signaling pathways. Through its interaction with the EphA2 receptor ephrin A1 regulates cytoskeletal dynamics and influences both integrin-mediated adhesion and cell migration. These pathways are important for maintaining cellular architecture and orchestrating cellular responses to environmental cues.
일반 정보
기능
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells (PubMed : 17332925, PubMed : 18794797). Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed : 12794130). May also contribute to dendritic spine morphogenesis (By similarity).
서열 유사성
Belongs to the ephrin family.
Post-translational modifications
Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.. N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
타겟 정보
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