Recombinant human ErbB3 / HER3 protein is a Human Fragment protein, in the 20 to 643 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, Mass Spec.
대체 명칭 보기
HER3, ERBB3, Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3
- Mass Cytometry
Supplier Data
Mass Cytometry - Recombinant human ErbB3 / HER3 protein (AB283452)
Mass determination by ESI-TOF.
Predicted MW is 68720 Da (+/- 10 Da by ESI-TOF). Observed molecular weight 68728.33 Da.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human ErbB3 / HER3 protein (AB283452)
SDS-PAGE analysis of ab283452.
- HPLC
Supplier Data
HPLC - Recombinant human ErbB3 / HER3 protein (AB283452)
HPLC analysis of ab283452.
보완 제품
Reagents, Controls & Accessories
AB325995
Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands)
- 0
- 0
Reactivity 정보
서열 정보
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HER3 is essential for activating important signaling pathways that regulate proliferation differentiation and survival. The ErbB3 protein forms heterodimers with other ErbB family members such as ErbB2 (HER2) which is necessary for its signaling capability. The HER3 protein is abundant in heart and nervous tissues indicating its role in cardiovascular and neurological functions. Its activation modulates gene expression through downstream effectors mediated by dimerization.
Pathways
HER3 plays a pivotal role in the PI3K/Akt and MAPK signaling pathways. These pathways are fundamental in cellular responses like growth and survival. HER3 serves as a major partner for HER2 in these signaling cascades enhancing downstream signaling effects. HER3's connection to these pathways makes it a critical node collaborating closely with proteins such as HER2 and EGFR to maintain efficient communication and function within these networks.
일반 정보
기능
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed : 20682778). May also be activated by CSPG5 (PubMed : 15358134). Involved in the regulation of myeloid cell differentiation (PubMed : 27416908).
서열 유사성
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-translational modifications
Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
타겟 정보
Product promise
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